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FLASH GENE

Symbol

MARCH4

contributors: mct - updated : 31-10-2012

HGNC name	membrane-associated ring finger (C3HC4) 4
HGNC id	29269

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020814 4 - 4466 NP_065865 - 410 - 2010 21151997

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly   pancreas exocrine       lowly Nervous brain       moderately Respiratory lung       highly Skin/Tegument skin       predominantly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RING-type zinc finger

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

MARCH family of membrane-bound E3 ubiquitin ligases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	integral to membrane

basic FUNCTION	acting as a ubiquitin-protein ligase
	role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins
	MARCH E3 ligases play a key role in controlling MHC class II surface expression by regulated ubiquitination of a lysine residue in the beta-chain

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ubiquitin ligase complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

ULBP1 is a target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS