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FLASH GENE

Symbol

MAPRE2

contributors: mct - updated : 04-03-2015

HGNC name	microtubule-associated protein, RP/EB family, member 2
HGNC id	6891

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CSCKT2 circumferential skin creases Kunze type syndrome 2
Location	18q12.1      Physical location : 32.556.891 - 32.722.377
Synonym name	APC-binding protein EB1
	APC-binding protein EB2
	End-binding protein 2
	T-cell activation protein, EB1 family
	adenomatous polyposis coli-binding protein EB2
Synonym symbol(s)	EVI135, EB1, EB2, RP1

DNA

TYPE	functioning gene
STRUCTURE	166.54 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	trannscription factor binding sites (CREB1 and CREB2)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014268 7 splicing 4279 NP_055083 37 327 - 2001 11161807 NM_001143826 8 splicing 4191 NP_001137298 32.1 284 - 2001 11161807 NM_001143827 8 splicing 4337 NP_001137299 35.6 315 - 2001 11161807 NM_001256420 6 - 4151 NP_001243349 - 274 - 2001 11161807

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       predominantly Homo sapiens Adult Nervous brain diencephalon amygdala       ganglia sensory ganglia dorsal root     Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Digestive acinar Homo sapiens Adult Endocrine islet cell (alpha,beta...) Homo sapiens Adult Lymphoid/Immune activated B lymphocyte

cell lineage
cell lines	predominant in most cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminus is sufficient for interaction with the COP9 signalosome

HOMOLOGY

intraspecies

homolog to MAPRE1,highly

Homologene

FAMILY	EB1/RP1 family
	putatively belonging to the immediate/early gene family
	EB family of proteins

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	in cells, MAPRE2 and CSN (COP9 signalosome) co-localize to the centrosome
	microtubule-associated protein

basic FUNCTION	promoting cytoplasmic microtubule dynamics and contributing to the control of cytokinesis checkpoint during mitosis
	playing a role in the proliferative control of normal cells
	master regulator of microtubule plus ends, controls microtubule growth and dynamics
	COP9 signalosome (CSN)-dependent protection of MAPRE2 is important for microtubule function
	is critical for microtubule reorganization during early stages of apico-basal epithelial differentiation
	MAPRE2 and CLIP1 are two well-studied microtubule plus-end-tracking proteins (+TIPs) that target growing microtubule plus ends in the form of comet tails and regulate microtubule dynamics
	MAPRE2 and CLIP1 cooperatively regulate microtubule dynamic instability at concentrations below which neither protein is effective

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to CLIP1, and forms a co-complex with CLIP1 and tubulin that is recruited to growing microtubule plus ends
	MAPRE2 binding is not limited to the microtubule (MT) seam, and potentially MAPRE2 binds cooperatively to MTs
	MAPRE2 association with HAX1 plays a significant role in focal adhesion turnover and epidermal migration

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CSCKT2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic cancer cells, and seems to be involved in perineural invasion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer

ANIMAL & CELL MODELS