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FLASH GENE
Symbol MAPRE2 contributors: mct - updated : 04-03-2013
HGNC name microtubule-associated protein, RP/EB family, member 2
HGNC id 6891
Corresponding disease
CSCKT2 circumferential skin creases Kunze type syndrome 2
Location 18q12.1      Physical location : 32.556.891 - 32.722.377
Synonym name
  • APC-binding protein EB1
  • APC-binding protein EB2
  • End-binding protein 2
  • T-cell activation protein, EB1 family
  • adenomatous polyposis coli-binding protein EB2
  • Synonym symbol(s) EVI135, EB1, EB2, RP1
    DNA
    TYPE functioning gene
    STRUCTURE 166.54 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure trannscription factor binding sites (CREB1 and CREB2)
    MAPPING cloned Y linked N status confirmed
    Physical map
    KIAA1384 18q12.1 KIAA1384 protein LOC374864 18q12.1 hypothetical protein LOC374864 LOC147354 18q12.1 similar to additional sex combs like 2; polycomb group protein ASXH2 KIAA1713 18q11 KIAA1713 protein NOL4 18q12 nucleolar protein 4 DTNA 18q12.1-q12.2 dystrobrevin, alpha LOC390849 18 similar to ribosomal protein L10a MAPRE2 18q12 microtubule-associated protein, RP/EB family, member 2 ZNF397 18q12.1 zinc finger protein 397 ZNF271 18q12 zinc finger protein 271 ZNF24 18q12 zinc finger protein 24 (KOX 17) ZNF396 18p12 zinc finger protein 396 LOC125476 18q12.2 hypothetical protein LOC125476 GALNT1 18q12.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) LOC388473 18 LOC388473 PNAS-131 18q12.2 hypothetical protein PNAS-131 P15RS 18q12.2 hypothetical protein FLJ10656 SLC39A6 18q12.2 solute carrier family 39 (zinc transporter), member 6 STATIP1 18q12.1 signal transducer and activator of transcription 3 interacting protein 1 MOCOS 18q12 molybdenum cofactor sulfurase RNU4P3 18q12.2 RNA, U4 small nuclear pseudogene 3 LOC390850 18 similar to RIKEN cDNA 0610008N23 KIAA1695 DKFZP586M1523 KIAA1328 18q12.2 KIAA1328 protein BRUNOL4 18q12 bruno-like 4, RNA binding protein (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 4279 37 327 - 2001 11161807
    8 splicing 4191 32.1 284 - 2001 11161807
    8 splicing 4337 35.6 315 - 2001 11161807
    6 - 4151 - 274 - 2001 11161807
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   predominantly Homo sapiensAdult
    Nervousbraindiencephalonamygdala  
     gangliasensory gangliadorsal root  
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveacinar Homo sapiensAdult
    Endocrineislet cell (alpha,beta...) Homo sapiensAdult
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines predominant in most cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminus is sufficient for interaction with the COP9 signalosome
  • HOMOLOGY
    intraspecies homolog to MAPRE1,highly
    Homologene
    FAMILY
  • EB1/RP1 family
  • putatively belonging to the immediate/early gene family
  • EB family of proteins
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • in cells, MAPRE2 and CSN (COP9 signalosome) co-localize to the centrosome
  • microtubule-associated protein
  • basic FUNCTION
  • promoting cytoplasmic microtubule dynamics and contributing to the control of cytokinesis checkpoint during mitosis
  • playing a role in the proliferative control of normal cells
  • master regulator of microtubule plus ends, controls microtubule growth and dynamics
  • COP9 signalosome (CSN)-dependent protection of MAPRE2 is important for microtubule function
  • is critical for microtubule reorganization during early stages of apico-basal epithelial differentiation
  • MAPRE2 and CLIP1 are two well-studied microtubule plus-end-tracking proteins (+TIPs) that target growing microtubule plus ends in the form of comet tails and regulate microtubule dynamics
  • MAPRE2 and CLIP1 cooperatively regulate microtubule dynamic instability at concentrations below which neither protein is effective
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to CLIP1, and forms a co-complex with CLIP1 and tubulin that is recruited to growing microtubule plus ends
  • MAPRE2 binding is not limited to the microtubule (MT) seam, and potentially MAPRE2 binds cooperatively to MTs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cells, and seems to be involved in perineural invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer
    ANIMAL & CELL MODELS