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FLASH GENE
Symbol MAPRE2 contributors: mct - updated : 04-03-2013
HGNC name microtubule-associated protein, RP/EB family, member 2
HGNC id 6891
DNA
TYPE functioning gene
STRUCTURE 166.54 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure trannscription factor binding sites (CREB1 and CREB2)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 4279 37 327 - 2001 11161807
8 splicing 4191 32.1 284 - 2001 11161807
8 splicing 4337 35.6 315 - 2001 11161807
6 - 4151 - 274 - 2001 11161807
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   predominantly Homo sapiensAdult
Nervousbraindiencephalonamygdala  
 gangliasensory gangliadorsal root  
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveacinar Homo sapiensAdult
Endocrineislet cell (alpha,beta...) Homo sapiensAdult
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines predominant in most cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus is sufficient for interaction with the COP9 signalosome
  • HOMOLOGY
    intraspecies homolog to MAPRE1,highly
    Homologene
    FAMILY
  • EB1/RP1 family
  • putatively belonging to the immediate/early gene family
  • EB family of proteins
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • in cells, MAPRE2 and CSN (COP9 signalosome) co-localize to the centrosome
  • microtubule-associated protein
  • basic FUNCTION
  • promoting cytoplasmic microtubule dynamics and contributing to the control of cytokinesis checkpoint during mitosis
  • playing a role in the proliferative control of normal cells
  • master regulator of microtubule plus ends, controls microtubule growth and dynamics
  • COP9 signalosome (CSN)-dependent protection of MAPRE2 is important for microtubule function
  • is critical for microtubule reorganization during early stages of apico-basal epithelial differentiation
  • MAPRE2 and CLIP1 are two well-studied microtubule plus-end-tracking proteins (+TIPs) that target growing microtubule plus ends in the form of comet tails and regulate microtubule dynamics
  • MAPRE2 and CLIP1 cooperatively regulate microtubule dynamic instability at concentrations below which neither protein is effective
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to CLIP1, and forms a co-complex with CLIP1 and tubulin that is recruited to growing microtubule plus ends
  • MAPRE2 binding is not limited to the microtubule (MT) seam, and potentially MAPRE2 binds cooperatively to MTs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cells, and seems to be involved in perineural invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer
    ANIMAL & CELL MODELS