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FLASH GENE
Symbol MAPRE2 contributors: mct - updated : 04-03-2013
HGNC name microtubule-associated protein, RP/EB family, member 2
HGNC id 6891
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus is sufficient for interaction with the COP9 signalosome
  • HOMOLOGY
    intraspecies homolog to MAPRE1,highly
    Homologene
    FAMILY
  • EB1/RP1 family
  • putatively belonging to the immediate/early gene family
  • EB family of proteins
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • in cells, MAPRE2 and CSN (COP9 signalosome) co-localize to the centrosome
  • microtubule-associated protein
  • basic FUNCTION
  • promoting cytoplasmic microtubule dynamics and contributing to the control of cytokinesis checkpoint during mitosis
  • playing a role in the proliferative control of normal cells
  • master regulator of microtubule plus ends, controls microtubule growth and dynamics
  • COP9 signalosome (CSN)-dependent protection of MAPRE2 is important for microtubule function
  • is critical for microtubule reorganization during early stages of apico-basal epithelial differentiation
  • MAPRE2 and CLIP1 are two well-studied microtubule plus-end-tracking proteins (+TIPs) that target growing microtubule plus ends in the form of comet tails and regulate microtubule dynamics
  • MAPRE2 and CLIP1 cooperatively regulate microtubule dynamic instability at concentrations below which neither protein is effective
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to CLIP1, and forms a co-complex with CLIP1 and tubulin that is recruited to growing microtubule plus ends
  • MAPRE2 binding is not limited to the microtubule (MT) seam, and potentially MAPRE2 binds cooperatively to MTs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer cells, and seems to be involved in perineural invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer
    ANIMAL & CELL MODELS