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FLASH GENE

Symbol

MAGED2

contributors: mct - updated : 26-12-2018

HGNC name	melanoma antigen, family D, 2
HGNC id	16353

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp11.2      Physical location : 54.834.170 - 54.842.445
Synonym name	hepatocellular carcinoma associated protein
	breast cancer associated gene 1
Synonym symbol(s)	11B6, BCG1, JCL-1, MAGE-D2, MAGED, HCA10

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	MAGED genes are clustered on chromosome Xp11
STRUCTURE	8.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

region moderately similar to necdin (NDN)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2080 65 606 - Harper variant 2 - - 2092 65 606 - Harper variant 3 - - 2174 65 606 - Harper

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Reproductive female system ovary     highly Urinary kidney         Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a MAGE domain

HOMOLOGY

interspecies	ortholog to murine Maged2
	ortholog to rattus Maged2

Homologene

FAMILY

melanoma antigen encoding gene (MAGE) family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	role of MAGED2 in tubular cell injury during kidney disease
	MAGED2, TRO and MAGEF1 had different effects depending on the type of breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   breast and gastric cancer, hepatocellular carcinoma constitutional germinal mutation       in X-linked mental retardation

Susceptibility

Variant & Polymorphism SNP

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS