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FLASH GENE
Symbol MAGED2 contributors: mct - updated : 26-12-2018
HGNC name melanoma antigen, family D, 2
HGNC id 16353
Location Xp11.2      Physical location : 54.834.170 - 54.842.445
Synonym name
  • hepatocellular carcinoma associated protein
  • breast cancer associated gene 1
  • Synonym symbol(s) 11B6, BCG1, JCL-1, MAGE-D2, MAGED, HCA10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text MAGED genes are clustered on chromosome Xp11
    STRUCTURE 8.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ACTGP10 Xp11.22-p11.21 actin, gamma pseudogene 10 SMCX Xp11.22-p11.21 Smcx homolog, X chromosome (mouse) KIAA0522 Xp11.23 KIAA0522 protein SMC1L1 Xp11.22-p11.21 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) FLJ32783 Xp11.23 hypothetical protein FLJ32783 HADH2 Xp11.2 hydroxyacyl-Coenzyme A dehydrogenase, type II UREB1 Xp11.23-p11.21 hydroxyacyl-Coenzyme A dehydrogenase, type II LOC389859 X similar to 28S ribosomal protein S18c, mitochondrial precursor (MRP-S18-c) (Mrps18c) (MRP-S18-1) (CGI-134) KIAA1111 Xp11.22 Homo sapiens KIAA1111 protein (KIAA1111), mRNA. FLJ20506 Xp11.22 hypothetical protein FLJ20506 PRKWNK3 Xp11.23-p11.21 protein kinase, lysine deficient 3 DT1P1A10 Xp11.22 hypothetical protein DT1P1A10 FGD1 Xp11.21 faciogenital dysplasia (Aarskog-Scott syndrome) FLJ10613 Xp11.22 hypothetical protein FLJ10613 LOC392473 X similar to dJ834A16.1 (similar to PGAM) UNQ6369 Xp11.22 ITI-like protein MAGED2 Xp11.2 melanoma antigen, family D, 2 TRO Xp11.22-p11.21 trophinin PFKFB1 Xp11.21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 APEX2 Xp11.22 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 ALAS2 Xp11.21 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) LOC389860 X similar to PAGE-5 protein LOC203569 Xp11.22 similar to PAGE-5 protein LOC90736 Xp11.22 hypothetical protein BC000919 PAGE-5 Xp11.22 PAGE-5 protein LOC139793 Xp11.22 similar to XAGE-5 protein MAGEH1 Xp11.22 APR-1 protein LOC158880 LOC392474 X similar to hypothetical protein MGC21658 Xp11.22 similar to Forkhead box protein N4 LOC392475 X similar to XAGE-5 protein RRAGB Xp11.21 Ras-related GTP binding B LOC392476 X similar to Got2-prov protein KLF8 Xp11.21 Kruppel-like factor 8
    regionally located region moderately similar to necdin (NDN)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2080 65 606 - Harper
    - - 2092 65 606 - Harper
    - - 2174 65 606 - Harper
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Reproductivefemale systemovary  highly
    Urinarykidneytubule  highly Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a MAGE domain
    HOMOLOGY
    interspecies ortholog to murine Maged2
    ortholog to rattus Maged2
    Homologene
    FAMILY melanoma antigen encoding gene (MAGE) family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    breast and gastric cancer, hepatocellular carcinoma
    constitutional germinal mutation      
    in X-linked mental retardation
    Susceptibility
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS