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FLASH GENE
Symbol MAGED2 contributors: mct - updated : 26-12-2018
HGNC name melanoma antigen, family D, 2
HGNC id 16353
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text MAGED genes are clustered on chromosome Xp11
STRUCTURE 8.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ACTGP10 Xp11.22-p11.21 actin, gamma pseudogene 10 SMCX Xp11.22-p11.21 Smcx homolog, X chromosome (mouse) KIAA0522 Xp11.23 KIAA0522 protein SMC1L1 Xp11.22-p11.21 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) FLJ32783 Xp11.23 hypothetical protein FLJ32783 HADH2 Xp11.2 hydroxyacyl-Coenzyme A dehydrogenase, type II UREB1 Xp11.23-p11.21 hydroxyacyl-Coenzyme A dehydrogenase, type II LOC389859 X similar to 28S ribosomal protein S18c, mitochondrial precursor (MRP-S18-c) (Mrps18c) (MRP-S18-1) (CGI-134) KIAA1111 Xp11.22 Homo sapiens KIAA1111 protein (KIAA1111), mRNA. FLJ20506 Xp11.22 hypothetical protein FLJ20506 PRKWNK3 Xp11.23-p11.21 protein kinase, lysine deficient 3 DT1P1A10 Xp11.22 hypothetical protein DT1P1A10 FGD1 Xp11.21 faciogenital dysplasia (Aarskog-Scott syndrome) FLJ10613 Xp11.22 hypothetical protein FLJ10613 LOC392473 X similar to dJ834A16.1 (similar to PGAM) UNQ6369 Xp11.22 ITI-like protein MAGED2 Xp11.2 melanoma antigen, family D, 2 TRO Xp11.22-p11.21 trophinin PFKFB1 Xp11.21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 APEX2 Xp11.22 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 ALAS2 Xp11.21 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) LOC389860 X similar to PAGE-5 protein LOC203569 Xp11.22 similar to PAGE-5 protein LOC90736 Xp11.22 hypothetical protein BC000919 PAGE-5 Xp11.22 PAGE-5 protein LOC139793 Xp11.22 similar to XAGE-5 protein MAGEH1 Xp11.22 APR-1 protein LOC158880 LOC392474 X similar to hypothetical protein MGC21658 Xp11.22 similar to Forkhead box protein N4 LOC392475 X similar to XAGE-5 protein RRAGB Xp11.21 Ras-related GTP binding B LOC392476 X similar to Got2-prov protein KLF8 Xp11.21 Kruppel-like factor 8
regionally located region moderately similar to necdin (NDN)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2080 65 606 - Harper
- - 2092 65 606 - Harper
- - 2174 65 606 - Harper
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
Urinarykidneytubule  highly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a MAGE domain
HOMOLOGY
interspecies ortholog to murine Maged2
ortholog to rattus Maged2
Homologene
FAMILY melanoma antigen encoding gene (MAGE) family
CATEGORY antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
breast and gastric cancer, hepatocellular carcinoma
constitutional germinal mutation      
in X-linked mental retardation
Susceptibility
Variant & Polymorphism SNP
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS