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FLASH GENE
Symbol MAGED2 contributors: mct - updated : 26-12-2018
HGNC name melanoma antigen, family D, 2
HGNC id 16353
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2080 65 606 - Harper
- - 2092 65 606 - Harper
- - 2174 65 606 - Harper
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
Urinarykidney     Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a MAGE domain
HOMOLOGY
interspecies ortholog to murine Maged2
ortholog to rattus Maged2
Homologene
FAMILY melanoma antigen encoding gene (MAGE) family
CATEGORY antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • role of MAGED2 in tubular cell injury during kidney disease
  • MAGED2, TRO and MAGEF1 had different effects depending on the type of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    breast and gastric cancer, hepatocellular carcinoma
    constitutional germinal mutation      
    in X-linked mental retardation
    Susceptibility
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS