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FLASH GENE
Symbol MAFF contributors: mct/npt - updated : 04-06-2008
HGNC name v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
HGNC id 6780
Location 22q13.1      Physical location : 38.597.938 - 38.612.515
Synonym name transcription factor MAFF
Synonym symbol(s) CTA-447C4.1, U-MAF
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LGALS1 22q13.1 lectin, galactoside-binding, soluble, 1 (galectin 1) MGC3731 22q13.1 hypothetical protein MGC3731 HRIHFB2122 22q13.1 hypothetical protein MGC3731 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13 C22orf23 22q13.1 chromosome 22 open reading frame 23 POLR2F 22q13.1 polymerase (RNA) II (DNA directed) polypeptide F SOX10 22q13.1 SRY (sex determining region Y)-box 10 LOC388899 22 LOC388899 PRKCABP 22q13.1 protein kinase C, alpha binding protein SLC16A8 22q12.3-q13.2 solute carrier 16 (monocarboxylic acid transporters), member 8 FLJ22582 22q13.1 hypothetical protein FLJ22582 PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon KCNJ4 22q13.1 potassium inwardly-rectifying channel, subfamily J, member 4 KDELR3 22q13.1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 DDX17 22q13.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 DMC1 22q13.1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) LOC388900 22 LOC388900 TOMM22 22q12-q13 translocase of outer mitochondrial membrane 22 homolog (yeast) C22orf2 22q12 chromosome 22 open reading frame 2
RNA
TRANSCRIPTS type messenger
text Variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2382 17.7 164 - Ye (2006)
3 - 2332 17.7 164 - Ye (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  highly
Urinarybladder   highly
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text in term, myometrium
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extended leucine zipper structure but without transactivation domain
  • a heptad-leucine repeat motif (viz., Leu-zipper) that may mediate protein-protein interactions to regulate transcriptional activities
  • HOMOLOGY
    Homologene
    FAMILY
  • V-maf musculoaponeurotic fibrosarcoma (ovarian) oncogene family protein F
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • binds to the oxytocin receptor (myometrium)
  • plays crucial roles in the control of gene expression and development
  • may be playing a specific role in proinflammatory cytokine-mediated control of myometrial gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with MIP (activated transcription efficiently)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS