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FLASH GENE
Symbol LTA contributors: np/ - updated : 23-05-2007
HGNC name lymphotoxin alpha (TNF superfamily, member 1)
HGNC id 6709
Location 6p21.33      Physical location : 2.825.414 - 31.542.098
Synonym name
  • tumor necrosis factor ligand superfamily member 1
  • tumor necrosis factor beta
    • Synonym symbol(s) TNFB, TNFSF1, DASS-280D8.1, LT, LT-alpha, TNF-beta
    EC.number 2.3.1.12
    DNA
    TYPE functioning gene
    STRUCTURE 2.22 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - HLA-B - FKBP1P1 - MICA - MICB - BAT1 - NFKBIL1 - LTA - LTB - KRT18P1 - HSPA1A - C2 C2 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1386 - 205 - -
    4 - 1459 - 205 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx    
    Lymphoid/Immunespleen    
     tonsils    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular C terminus, bearing the ligand binding region
    • conjugated GlycoP
    mono polymer homomer , heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumors necrosis factor (ligand) family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 2
    basic FUNCTION
  • involved in the formation of secondary lymphoid organs during development and playing a role in apoptosis
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LGALS2
    • cell & other
    REGULATION
    Other regulated by LGALS2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to myocardial infarction
  • to early-onset leprosy
  • to psoriatic arthritis
    • Variant & Polymorphism SNP , other
  • increased risk of myocardial infarction
  • (LTA)+80 A allele was significantly associated with an increase in early-onset leprosy risk
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheromacardiac
    metabolismlipid 
    may represent a novel therapeutic route for the treatment of dyslipidemia
    ANIMAL & CELL MODELS