Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LAMTOR3 contributors: mct/pgu - updated : 31-05-2010
HGNC name MAPK scaffold protein 1
HGNC id 15606
Location 4q23      Physical location : -
Synonym name
  • MEK partner
  • mitogen-activated protein kinase kinase 1 interacting protein 1
  • MEK-binding partner 1
  • ragulator complex protein LAMTOR3
    • Synonym symbol(s) MP1, MAP2K1IP1, MAPBP, PRO0633, MAPKSP1, p14
    DNA
    TYPE functioning gene
    STRUCTURE 16.21 kb     7 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4280 - 124 - 1998 9733512
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Map2k1ip1 (96.8 pc)
    homolog to murine Mapksp1 (97.6 pc)
    Homologene
    FAMILY
  • MAPKSP1 family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text
  • late endosome membrane, cytoplasmic side
    • basic FUNCTION
  • acting as an adapter protein that enhances the efficiency of the MAP kinase cascade
  • facilitating the activation of MAPK2
  • involved in late endosomal traffic and cell proliferation
  • have the potential to differentially modulate activating and inhibiting signals in the RAF-MKK1/2-ERK1/2 pathway
  • inhibiting Rho/Rho kinase functions necessary for the turnover of adhesion structures and cell spreading
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with MAPBPIP
  • component of the Ragulator complex (MAPKSP1, ROBLD3, LAMTOR1) involved in targeting MTOR to the lysosomal surface and in its activation by amino acids
  • LAMTOR3 is a scaffold protein in the RAF/MEK/ERK pathway and together with LAMTOR2 forms a heterodimer that was shown to be responsible for localization of MEK to the late endosomal compartment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP2K1, MAPK2, MAPK3 and MAPK1
  • interacting with MORG1
  • associating with active PAK1 and controling PAK1 phosphorylation of MEK1
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • LAMTOR1 is a binding partner of LAMTOR3/LAMTOR2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS