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FLASH GENE
Symbol LAMTOR3 contributors: mct/pgu - updated : 31-05-2010
HGNC name MAPK scaffold protein 1
HGNC id 15606
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Map2k1ip1 (96.8 pc)
homolog to murine Mapksp1 (97.6 pc)
Homologene
FAMILY
  • MAPKSP1 family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text
  • late endosome membrane, cytoplasmic side
    • basic FUNCTION
  • acting as an adapter protein that enhances the efficiency of the MAP kinase cascade
  • facilitating the activation of MAPK2
  • involved in late endosomal traffic and cell proliferation
  • have the potential to differentially modulate activating and inhibiting signals in the RAF-MKK1/2-ERK1/2 pathway
  • inhibiting Rho/Rho kinase functions necessary for the turnover of adhesion structures and cell spreading
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with MAPBPIP
  • component of the Ragulator complex (MAPKSP1, ROBLD3, LAMTOR1) involved in targeting MTOR to the lysosomal surface and in its activation by amino acids
  • LAMTOR3 is a scaffold protein in the RAF/MEK/ERK pathway and together with LAMTOR2 forms a heterodimer that was shown to be responsible for localization of MEK to the late endosomal compartment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP2K1, MAPK2, MAPK3 and MAPK1
  • interacting with MORG1
  • associating with active PAK1 and controling PAK1 phosphorylation of MEK1
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • LAMTOR1 is a binding partner of LAMTOR3/LAMTOR2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS