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FLASH GENE

Symbol

LAMTOR3

contributors: mct/pgu - updated : 31-05-2010

HGNC name	MAPK scaffold protein 1
HGNC id	15606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.21 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021970 7 - 4280 NP_068805 - 124 - 1998 9733512

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Map2k1ip1 (96.8 pc)
	homolog to murine Mapksp1 (97.6 pc)

Homologene

FAMILY

MAPKSP1 family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
text	late endosome membrane, cytoplasmic side

basic FUNCTION	acting as an adapter protein that enhances the efficiency of the MAP kinase cascade
	facilitating the activation of MAPK2
	involved in late endosomal traffic and cell proliferation
	have the potential to differentially modulate activating and inhibiting signals in the RAF-MKK1/2-ERK1/2 pathway
	inhibiting Rho/Rho kinase functions necessary for the turnover of adhesion structures and cell spreading

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimer with MAPBPIP
	component of the Ragulator complex (MAPKSP1, ROBLD3, LAMTOR1) involved in targeting MTOR to the lysosomal surface and in its activation by amino acids
	LAMTOR3 is a scaffold protein in the RAF/MEK/ERK pathway and together with LAMTOR2 forms a heterodimer that was shown to be responsible for localization of MEK to the late endosomal compartment

INTERACTION

DNA

RNA

small molecule

protein	interacting with MAP2K1, MAPK2, MAPK3 and MAPK1
	interacting with MORG1
	associating with active PAK1 and controling PAK1 phosphorylation of MEK1
	a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
	LAMTOR1 is a binding partner of LAMTOR3/LAMTOR2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS