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FLASH GENE
Symbol LAMB2 contributors: mct - updated : 26-02-2011
HGNC name laminin, beta 2 (laminin S)
HGNC id 6487
Corresponding disease
MCCNS microcoria-congenital nephrosis and myasthenic syndrome
Location 3p21.31      Physical location : 49.158.547 - 49.170.599
Synonym name
  • laminin S
  • laminin B1s chain
  • laminin subunit beta-2
  • Synonym symbol(s) LAMS
    DNA
    TYPE functioning gene
    STRUCTURE 12.05 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S4594 - LAMB2L - LAMB2 - QARS - DAG1 - cen
    Authors Durkin (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 5817 - 1798 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Endocrinethyroid   moderately
    Lymphoid/Immunespleen   moderately
    Nervousnervecranial nerve  highly
     spinal cord   moderately
    Reproductivefemale systemuterus  highly
    Respiratorylung   moderately
     respiratory tracttrachea  moderately
    Urinarykidneynephronrenal capsuleglomerulushighly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Lymphoid    
    Membranebasement   
    Muscularsmoothciliary muscle  
    Muscularsmoothiris  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic tissue at a moderately level
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 4 laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by
  • 13 EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
  • a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • C-terminal region of beta chains is involved in laminin recognition by integrins and modulates the binding affinities of laminins toward X2-type integrins
  • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Lamb2 (88.04 pc)
    homolog to murine Lamb2 (88.42 pc)
    intraspecies homolog to LAMB1
    Homologene
    FAMILY
  • laminin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text glomeruli, nerve fascicle perineurium, vascular, basement membrane of neuromuscular junction (matrix and synaptic cleft of the neuromuscular junction)
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • playing a role in anchoring as well as differentiation of podocytes foot processes
  • basement membrane protein laminin beta2, which is incorporated in specific heterotrimeric laminin isoforms
  • essential component of the basement membrane
  • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of basement membrane zone
  • heterotrimerizing with laminin alpha and laminin gamma subunits
  • bÍta subunit of laminin 3, laminin 4, laminin 7, laminin 11, laminin 13 and laminin 15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to voltage-gated calcium channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS