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FLASH GENE
Symbol QARS contributors: mct - updated : 18-04-2014
HGNC name glutaminyl-tRNA synthetase
HGNC id 9751
Corresponding disease
MCCH2 microcephaly with cerebellar hypoplasia syndrome 2
Location 3p21.31      Physical location : 49.133.365 - 49.142.171
Synonym name glutamine tRNA ligase
Synonym symbol(s) GLNRS, PRO2195
EC.number 6.1.1.18
DNA
TYPE functioning gene
STRUCTURE 9.19 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
SRP 3p21.3 stresscopin-related peptide COL7A1 3p21.3 collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) UQCRC1 3p21.2 ubiquinol-cytochrome c reductase core protein I LOC344651 3p21.31 hypothetical LOC344651 SLC26A6 3p21 solute carrier family 26, member 6 CELSR3 3p24.1-p21.2 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) AF3P21 3p21 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) IHPK2 3p21.31 inositol hexaphosphate kinase 2 PRKAR2A 3p21.3-p21.2 protein kinase, cAMP-dependent, regulatory, type II, alpha SLC25A20 3p21.31 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ARIH2 3p21.2-p21.3 ariadne homolog 2 (Drosophila) PH-4 3p21.31 hypoxia-inducible factor prolyl 4-hydroxylase WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene) GPX1 3p21.2 glutathione peroxidase 1 ARHA 3p21.2 ras homolog gene family, member A TCTA 3p21 T-cell leukemia translocation altered gene AMT 3p21.2 aminomethyltransferase (glycine cleavage system protein T) NICN1 3p21.31 nicolin 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 2810 - 764 - Ko (2001)
24 - 2843 88 775 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrainforebraincerebral cortex highly Homo sapiensFetal
Urinarykidney   highly
cell lineage
cell lines tumor cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • N-terminal domain of QARS is suggested to interact with arginyl-tRNA synthetase
  • HOMOLOGY
    interspecies homolog to C.elegans y41e3.4
    Homologene
    FAMILY
  • class 1 aminoacyl tRNA synthetase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • endogenous QARS was mainly distributed in the cytoplasm and showed a similar localization pattern to an endoplasmic reticulum (ER) protein, but not a Golgi protein
  • basic FUNCTION
  • is required for the dendritic and axonal terminal arborization during development
  • important role of QARS during brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP3K5 (inhibiting its activity)
  • have glutamine-dependent antiapoptotic functions through binding to ASK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS