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FLASH GENE
Symbol QARS contributors: mct - updated : 18-04-2014
HGNC name glutaminyl-tRNA synthetase
HGNC id 9751
Corresponding disease
MCCH2 microcephaly with cerebellar hypoplasia syndrome 2
Location 3p21.31      Physical location : 49.133.365 - 49.142.171
Synonym name glutamine tRNA ligase
Synonym symbol(s) GLNRS, PRO2195
EC.number 6.1.1.18
DNA
TYPE functioning gene
STRUCTURE 9.19 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 2810 - 764 - Ko (2001)
24 - 2843 88 775 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrainforebraincerebral cortex highly Homo sapiensFetal
Urinarykidney   highly
cell lineage
cell lines tumor cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • N-terminal domain of QARS is suggested to interact with arginyl-tRNA synthetase
  • HOMOLOGY
    interspecies homolog to C.elegans y41e3.4
    Homologene
    FAMILY
  • class 1 aminoacyl tRNA synthetase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • endogenous QARS was mainly distributed in the cytoplasm and showed a similar localization pattern to an endoplasmic reticulum (ER) protein, but not a Golgi protein
  • basic FUNCTION
  • is required for the dendritic and axonal terminal arborization during development
  • important role of QARS during brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP3K5 (inhibiting its activity)
  • have glutamine-dependent antiapoptotic functions through binding to ASK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS