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FLASH GENE
Symbol KRT3 contributors: npt - updated : 04/10/2008
HGNC name keratin 3
HGNC id 6440
Corresponding disease
CDM1 corneal dystrophy, juvenile epitihelial 1, of Meesmann
Location 12q13      Physical location : 53.183.469 - 53.189.892
Synonym name
  • keratin, type II cytoskeletal 3
  • cytokeratin 3
  • 65 kDa cytokeratin
  • Synonym symbol(s) K3, CK3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text type II cytokeratins are clustered in a region of chromosome 12q12-q13
    STRUCTURE 6.42 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    KRTHB4 12q13 keratin, hair, basic, 4 KRTHB2 12q13 keratin, hair, basic, 2 KRTHBP1 12q13 keratin, hair, basic, pseudogene 1 K6HF 12q13 cytokeratin type II KRT6B 12q13.1-q13.2 keratin 6B KRT6E 12q13.13 keratin 6E KRT6A 12q13 keratin 6A KRT6C 12q12-q13 keratin 6C KRT5 12q13.2-q13.3 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) KRT6IRS 12q13.13 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) K6IRS4 12q13.13 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) K6IRS2 12q13.13 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) K6IRS3 12q13.3 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) KRT2A 12q13.1-q13.2 keratin 2A (epidermal ichthyosis bullosa of Siemens) KRT1 12q13 keratin 1 (epidermolytic hyperkeratosis) LOC387860 12 similar to keratin 1b LOC341409 12q13.13 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 LOC387861 12 similar to K+ channel tetramerization protein HUMCYT2A 12q13.13 cytokeratin 2 KRT3 12q13 keratin 3 KRT4 12q13 keratin 4 KRT6L 12q13.13 keratin 6L K5B 12q13.13 keratin 5b KRT8 12q13 keratin 8 KRT18 12q13 keratin 18 EIF4B 12q13.13 eukaryotic translation initiation factor 4B PRO1843 12q13.13 hypothetical protein PRO1843 TENC1 12q12 tensin like C1 domain-containing phosphatase FLJ14800 12q13.13 hypothetical protein FLJ14800
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2327 - 628 - Schweizer (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tractlarynx   
    Visualeyeanterior segmentcornea specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningcorneal epithelium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text during corneal differentiation of epithelia specifically
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • specifically expressed in the corneal epithelium with family member KRT12
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cytoskeleton organization and biogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • basic or neutral proteins which are arranged in pairs of heterotypic keratin chains with KRT12
  • heterotetramer of two type I and two type II keratins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDM1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS