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FLASH GENE
Symbol KRT3 contributors: npt - updated : 04/10/2008
HGNC name keratin 3
HGNC id 6440
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2327 - 628 - Schweizer (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractlarynx   
Visualeyeanterior segmentcornea specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningcorneal epithelium  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text during corneal differentiation of epithelia specifically
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • specifically expressed in the corneal epithelium with family member KRT12
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cytoskeleton organization and biogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • basic or neutral proteins which are arranged in pairs of heterotypic keratin chains with KRT12
  • heterotetramer of two type I and two type II keratins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDM1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS