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FLASH GENE
Symbol KRT3 contributors: npt - updated : 04/10/2008
HGNC name keratin 3
HGNC id 6440
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • specifically expressed in the corneal epithelium with family member KRT12
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cytoskeleton organization and biogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • basic or neutral proteins which are arranged in pairs of heterotypic keratin chains with KRT12
  • heterotetramer of two type I and two type II keratins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDM1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS