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FLASH GENE
Symbol KLRF1 contributors: mct/npt - updated : 02-06-2010
HGNC name killer cell lectin-like receptor subfamily F, member 1
HGNC id 13342
Location 12p13.31      Physical location : 9.980.076 - 9.997.601
Synonym name
  • killer cell lectin-like receptor F1
  • activating coreceptor NKp80
  • C-type lectin domain family 5 member C
  • Synonym symbol(s) CLEC5C, MGC119907, MGC119908, MGC119909, NKp80, ML
    DNA
    TYPE functioning gene
    STRUCTURE 17.53 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located between CLECSF2 and OLR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1242 - 231 - Roda-Navarro (2001)
    - - 950 - 79 - Roda-Navairo (2001)
  • also called KLRF1-S2
  • lacking the CTLD
  • - - 840 - 64 - Roda-Navairo (2001)
  • also called KLRF1-S3
  • lacking the CTLD
  • - - 1090 - 191 - Roda-Navairo (2001)
  • also called KLRF1 -S
  • lacking the STALK domain
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage myeloid cell lines
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text heart, pregnant uterus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 42 AA cytoplasmic region with two immunoreceptor tyrosine based inhibitory-like motifs
  • one lectin C type domain in the 166 AA extracellular region (C TLD)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • involved in the regulation of natural killer cell activity
  • activating homodimeric C-type lectin-like receptor (CTLR), expressed on essentially all human natural killer (NK) cells that stimulates their cytotoxicity and cytokine release (Kuttruff 2009)
  • may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation (Kuttruff 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other inhibitor in NK cell and monocyte activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of LRK1 and KLRF1 ligands by Kaposi sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS