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FLASH GENE
Symbol KLRF1 contributors: mct/npt - updated : 02-06-2010
HGNC name killer cell lectin-like receptor subfamily F, member 1
HGNC id 13342
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage myeloid cell lines
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text heart, pregnant uterus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 42 AA cytoplasmic region with two immunoreceptor tyrosine based inhibitory-like motifs
  • one lectin C type domain in the 166 AA extracellular region (C TLD)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • involved in the regulation of natural killer cell activity
  • activating homodimeric C-type lectin-like receptor (CTLR), expressed on essentially all human natural killer (NK) cells that stimulates their cytotoxicity and cytokine release (Kuttruff 2009)
  • may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation (Kuttruff 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other inhibitor in NK cell and monocyte activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of LRK1 and KLRF1 ligands by Kaposi sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS