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FLASH GENE

Symbol

KLRF1

contributors: mct/npt - updated : 02-06-2010

HGNC name	killer cell lectin-like receptor subfamily F, member 1
HGNC id	13342

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.53 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

between CLECSF2 and OLR1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016523 6 - 1242 NP_057607 - 231 - Roda-Navarro (2001) variant 3 - - 950 isoform 3 - 79 - Roda-Navairo (2001) also called KLRF1-S2 lacking the CTLD variant 4 - - 840 isoform 4 - 64 - Roda-Navairo (2001) also called KLRF1-S3 lacking the CTLD variant 2 - - 1090 isoform 2 - 191 - Roda-Navairo (2001) also called KLRF1 -S lacking the STALK domain

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune natural killer Lymphoid/Immune T cell

cell lineage	myeloid cell lines
cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	heart, pregnant uterus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	42 AA cytoplasmic region with two immunoreceptor tyrosine based inhibitory-like motifs
	one lectin C type domain in the 166 AA extracellular region (C TLD)

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II membrane protein

basic FUNCTION	involved in the regulation of natural killer cell activity
	activating homodimeric C-type lectin-like receptor (CTLR), expressed on essentially all human natural killer (NK) cells that stimulates their cytotoxicity and cytokine release (Kuttruff 2009)
	may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation (Kuttruff 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

inhibitor in NK cell and monocyte activity

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   of LRK1 and KLRF1 ligands by Kaposi sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS