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FLASH GENE
Symbol KLK5 contributors: mct/pgu - updated : 10-07-2017
HGNC name kallikrein-related peptidase 5
HGNC id 6366
Location 19q13.41      Physical location : 51.446.560 - 51.456.344
Synonym name
  • kallikrein-like protein 2
  • stratum corneum tryptic enzyme
  • kallikrein 5
  • Synonym symbol(s) KLKL2, SCTE
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, overlapping
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 9.79 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7 LOC284367 19q13.41 hypothetical protein LOC284367 SIGLECP1 19q13.33 sialic acid binding Ig-like lectin, pseudogene 1 CD33 19q13.3 CD33 antigen (gp67)
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1435 - 293 - 2000 10969073
    6 - 1367 - 293 - 2000 10969073
    6 - 1570 - 293 - 2000 10969073
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland     Homo sapiens
    Reproductivefemale systembreast    Homo sapiens
    Skin/Tegumentskin   highly Homo sapiens
    Urinarykidneytubule  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text
  • keratinocyte
  • in the skin, SPINK5, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized
  • basic FUNCTION
  • having trypsin, but not chymotrypsin-like, activity
  • in normal skin, involved in desquamation during epidermal differentiation via proteolytic cleavage of the desmosomal cadherin component desmoglein
  • key actor of the desquamation process, as the major target of SPINK5
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates
  • may potentially promote metastatic dissemination of oral squamous cell carcinoma by promoting loss of junctional integrity through cleavage of desmoglein 1 (DSG1)
  • may potentiate metastatic dissemination of oral squamous cell carcinoma by contributing to dissolution of DSG1-containing cell-cell contacts, thereby modifying epithelial cohesion
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of SPINK5
  • interacting with DSG1 (KLK5 action may destabilize DSG1 structure and abolish adhesion to desmocollins on neighboring cells)
  • the actions of KLK7 are tightly controlled by PI3 and SPINK5, which also inhibits KLK5, localizing protease activity to the stratum corneum
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast and ovarian cancer
    tumoral     --over  
    in squamous cell carcinoma of the lung
    tumoral     --over  
    in oral squamous cell carcinoma and may be implicated in malignant progression
    tumoral     --low  
    in prostate and breast cancers
    constitutional     --other  
    unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential biomarkers for breast cancer
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS