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FLASH GENE
Symbol KLK5 contributors: mct/pgu - updated : 10-07-2017
HGNC name kallikrein-related peptidase 5
HGNC id 6366
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text
  • keratinocyte
  • in the skin, SPINK5, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized
  • basic FUNCTION
  • having trypsin, but not chymotrypsin-like, activity
  • in normal skin, involved in desquamation during epidermal differentiation via proteolytic cleavage of the desmosomal cadherin component desmoglein
  • key actor of the desquamation process, as the major target of SPINK5
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates
  • may potentially promote metastatic dissemination of oral squamous cell carcinoma by promoting loss of junctional integrity through cleavage of desmoglein 1 (DSG1)
  • may potentiate metastatic dissemination of oral squamous cell carcinoma by contributing to dissolution of DSG1-containing cell-cell contacts, thereby modifying epithelial cohesion
  • KLK5, KLK12 are involved in the cleavage activation of human-adapted influenza virus subtypes
  • KLK5, KLK7 and KLK14 are important proteases in skin desquamation
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of SPINK5
  • interacting with DSG1 (KLK5 action may destabilize DSG1 structure and abolish adhesion to desmocollins on neighboring cells)
  • the actions of KLK7 are tightly controlled by PI3 and SPINK5, which also inhibits KLK5, localizing protease activity to the stratum corneum
  • KLK5 and KLK8 remove the N-terminal eight AAs from the proform thereby converting CCL14 to its active state
  • SPINK5 tightly controls the activities of serine proteases such as kallikrein-related peptidase KLK5 and KLK7 in the epidermis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast and ovarian cancer
    tumoral     --over  
    in squamous cell carcinoma of the lung
    tumoral     --over  
    in oral squamous cell carcinoma and may be implicated in malignant progression
    tumoral     --low  
    in prostate and breast cancers
    constitutional     --other  
    unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential biomarkers for breast cancer
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS