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FLASH GENE
Symbol KLK5 contributors: mct/pgu - updated : 10-07-2017
HGNC name kallikrein-related peptidase 5
HGNC id 6366
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast and ovarian cancer
tumoral     --over  
in squamous cell carcinoma of the lung
tumoral     --over  
in oral squamous cell carcinoma and may be implicated in malignant progression
tumoral     --low  
in prostate and breast cancers
constitutional     --other  
unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development
Susceptibility
Variant & Polymorphism
Candidate gene potential biomarkers for breast cancer
Marker
Therapy target
SystemTypeDisorderPubmed
miscelleaneousdermatology 
potential target for the treatment of skin disorders in which KLK activity is elevated
ANIMAL & CELL MODELS