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FLASH GENE
Symbol KLK13 contributors: mct - updated : 02-04-2020
HGNC name kallikrein-related peptidase 13
HGNC id 6361
Location 19q13.41      Physical location : 51.559.463 - 51.568.367
Synonym name
  • kallikrein-like 4, neuropsin
  • kallikrein 13
  • kallikrein-like protein 4
  • Synonym symbol(s) KLK-L4, KLKL4, DKFZp586J1923
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 9.48 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1820 - 277 - 2001 11848466
    3 - 1364 - 125 - 2001 11848466
    5 - 1601 - 204 - 2001 11848466
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly Homo sapiens
     salivary gland   highly Homo sapiens
    Lymphoid/Immunetonsils     Homo sapiens
    Reproductivefemale systemuteruscervix   Homo sapiens
     male systemtestis    Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarykidneytubule  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to KLK11,KLK6
    Homologene
    FAMILY
  • kallikrein family
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text localized in the cytoplasm of epithelial cells of normal bronchus
    basic FUNCTION
  • involved in the pathogenesis and/or progression of breast cancer
  • may play a role in tissue remodeling and/or tumor invasion and metastasis
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • may play a role in the defense of the upper digestive apparatus and in male reproductive organs
  • may play an important role in regulating cellular migration and invasiveness
  • KLK13 and TMPRSS11D are candidate active proteases in the Cervical-vaginal fluid (CVF)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinin B1 receptor agonist induces secretion of KLK1, KLK6, KLK10, KLK13 and KLK14 into the medium nof neutrophils
  • cell & other
    REGULATION
    induced by steroid hormone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KLK6 and KLK13 in ovarian cancer compared to normal ovarian tissues
    tumoral     --over  
    significantly increased in invasive cancers relative to normal ovaries
    tumoral     --over  
    in breast cancer with good prognostic
    tumoral     --over  
    in several common salivary gland tumors
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC) were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis
    tumoral     --low  
    in bladder tumors and is correlated with disease aggressiveness, including higher tumor stage and grade
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • tumor biomarker capable of predicting a favorable outcome for gastric cancer patients ,
  • potential biomarkers that can significantly predict prognosis in terms of recurrence-free survival and overall survival in ovarian cancer
  • loss of KLK13 a potential biomarker for early detection of lymph node metastasis in OSCCs
  • KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in NSCLC (nonsmall cell lung cancer)
  • MUC16 and KLK13 represent independent prognostic markers for colon cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be therapeutic targets for treatment of ovarian cancer
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS