Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KLK13 contributors: mct - updated : 02-04-2020
HGNC name kallikrein-related peptidase 13
HGNC id 6361
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly Homo sapiens
 salivary gland   highly Homo sapiens
Lymphoid/Immunetonsils     Homo sapiens
Reproductivefemale systemuteruscervix   Homo sapiens
 male systemtestis    Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidneytubule  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
intraspecies homolog to KLK11,KLK6
Homologene
FAMILY
  • kallikrein family
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text localized in the cytoplasm of epithelial cells of normal bronchus
    basic FUNCTION
  • involved in the pathogenesis and/or progression of breast cancer
  • may play a role in tissue remodeling and/or tumor invasion and metastasis
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • may play a role in the defense of the upper digestive apparatus and in male reproductive organs
  • may play an important role in regulating cellular migration and invasiveness
  • KLK13 and TMPRSS11D are candidate active proteases in the Cervical-vaginal fluid (CVF)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinin B1 receptor agonist induces secretion of KLK1, KLK6, KLK10, KLK13 and KLK14 into the medium nof neutrophils
  • cell & other
    REGULATION
    induced by steroid hormone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KLK6 and KLK13 in ovarian cancer compared to normal ovarian tissues
    tumoral     --over  
    significantly increased in invasive cancers relative to normal ovaries
    tumoral     --over  
    in breast cancer with good prognostic
    tumoral     --over  
    in several common salivary gland tumors
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC) were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis
    tumoral     --low  
    in bladder tumors and is correlated with disease aggressiveness, including higher tumor stage and grade
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • tumor biomarker capable of predicting a favorable outcome for gastric cancer patients ,
  • potential biomarkers that can significantly predict prognosis in terms of recurrence-free survival and overall survival in ovarian cancer
  • loss of KLK13 a potential biomarker for early detection of lymph node metastasis in OSCCs
  • KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in NSCLC (nonsmall cell lung cancer)
  • MUC16 and KLK13 represent independent prognostic markers for colon cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be therapeutic targets for treatment of ovarian cancer
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS