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FLASH GENE
Symbol KLK13 contributors: mct - updated : 02-04-2020
HGNC name kallikrein-related peptidase 13
HGNC id 6361
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
intraspecies homolog to KLK11,KLK6
Homologene
FAMILY
  • kallikrein family
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text localized in the cytoplasm of epithelial cells of normal bronchus
    basic FUNCTION
  • involved in the pathogenesis and/or progression of breast cancer
  • may play a role in tissue remodeling and/or tumor invasion and metastasis
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • may play a role in the defense of the upper digestive apparatus and in male reproductive organs
  • may play an important role in regulating cellular migration and invasiveness
  • KLK13 and TMPRSS11D are candidate active proteases in the Cervical-vaginal fluid (CVF)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinin B1 receptor agonist induces secretion of KLK1, KLK6, KLK10, KLK13 and KLK14 into the medium nof neutrophils
  • cell & other
    REGULATION
    induced by steroid hormone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KLK6 and KLK13 in ovarian cancer compared to normal ovarian tissues
    tumoral     --over  
    significantly increased in invasive cancers relative to normal ovaries
    tumoral     --over  
    in breast cancer with good prognostic
    tumoral     --over  
    in several common salivary gland tumors
    tumoral     --over  
    in esophageal squamous cell carcinoma (ESCC) were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis
    tumoral     --low  
    in bladder tumors and is correlated with disease aggressiveness, including higher tumor stage and grade
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • tumor biomarker capable of predicting a favorable outcome for gastric cancer patients ,
  • potential biomarkers that can significantly predict prognosis in terms of recurrence-free survival and overall survival in ovarian cancer
  • loss of KLK13 a potential biomarker for early detection of lymph node metastasis in OSCCs
  • KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in NSCLC (nonsmall cell lung cancer)
  • MUC16 and KLK13 represent independent prognostic markers for colon cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be therapeutic targets for treatment of ovarian cancer
    miscelleaneousdermatology 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    ANIMAL & CELL MODELS