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FLASH GENE
Symbol KIF20B contributors: mct/npt - updated : 24-03-2009
HGNC name kinesin family member 20B
HGNC id 7212
Location 10q23.31      Physical location : 91.461.366 - 91.534.700
Synonym name
  • mitotic kinesin-like protein
  • M-phase phosphoprotein 1
  • cancer/testis antigen 90
  • kinesin-related motor interacting with PIN1
    • Synonym symbol(s) MPP1, KRMP1, MPHOSPH1, CT90, DKFZp434B0435, DKFZp434P0810
    DNA
    TYPE functioning gene
    STRUCTURE 73.33 kb     33 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 6319 206 1780 - Kamimoto (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • kinesin motor domain at the N terminus
  • central stalk domain forming a long alpha -helical coiled-coil
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • kinesin like protein family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • localizes mainly to the nuclei in interphase
  • during mitosis, diffuse throughout the cytoplasm in metaphase and subsequently localizes to the midzone to further concentrate on the midbody (Abaza 2003)
    • basic FUNCTION
  • may act as a motor required for the retrograde RAB6 regulated transport of golgi membranes and associated vesicles along microtubules
  • mitotic molecular motor required for completion of cytokinesis (Abaza 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MPHOSPH1/PRC1 complex is likely to play a crucial role in bladder carcinogenesis (Kanehira 2007)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitotic peptidyl prolyl isomerase PIN1(to regulate MPHOSPH1)
  • interaction between MPHOSPH1 and protein regulator of cytokinesis 1 (PRC1) (Kanehira 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of bladder cancers (Kanehira 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target inhibition of the KIF20B/PRC1 expression or their interaction should be novel therapeutic targets for bladder cancers (Kanehira 2007)
    ANIMAL & CELL MODELS