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FLASH GENE
Symbol KIF20B contributors: mct/npt - updated : 24-03-2009
HGNC name kinesin family member 20B
HGNC id 7212
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • kinesin motor domain at the N terminus
  • central stalk domain forming a long alpha -helical coiled-coil
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • kinesin like protein family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • localizes mainly to the nuclei in interphase
  • during mitosis, diffuse throughout the cytoplasm in metaphase and subsequently localizes to the midzone to further concentrate on the midbody (Abaza 2003)
    • basic FUNCTION
  • may act as a motor required for the retrograde RAB6 regulated transport of golgi membranes and associated vesicles along microtubules
  • mitotic molecular motor required for completion of cytokinesis (Abaza 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MPHOSPH1/PRC1 complex is likely to play a crucial role in bladder carcinogenesis (Kanehira 2007)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitotic peptidyl prolyl isomerase PIN1(to regulate MPHOSPH1)
  • interaction between MPHOSPH1 and protein regulator of cytokinesis 1 (PRC1) (Kanehira 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of bladder cancers (Kanehira 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target inhibition of the KIF20B/PRC1 expression or their interaction should be novel therapeutic targets for bladder cancers (Kanehira 2007)
    ANIMAL & CELL MODELS