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FLASH GENE

Symbol

KIF20B

contributors: mct/npt - updated : 24-03-2009

HGNC name	kinesin family member 20B
HGNC id	7212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	73.33 kb     33 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KIF20B 33 - 6319 206 1780 - Kamimoto (2001)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system testis     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, M

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	kinesin motor domain at the N terminus
	central stalk domain forming a long alpha -helical coiled-coil

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

kinesin like protein family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus
text	localizes mainly to the nuclei in interphase
	during mitosis, diffuse throughout the cytoplasm in metaphase and subsequently localizes to the midzone to further concentrate on the midbody (Abaza 2003)

basic FUNCTION	may act as a motor required for the retrograde RAB6 regulated transport of golgi membranes and associated vesicles along microtubules
	mitotic molecular motor required for completion of cytokinesis (Abaza 2003)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MPHOSPH1/PRC1 complex is likely to play a crucial role in bladder carcinogenesis (Kanehira 2007)

INTERACTION

DNA

RNA

small molecule

protein	mitotic peptidyl prolyl isomerase PIN1(to regulate MPHOSPH1)
	interaction between MPHOSPH1 and protein regulator of cytokinesis 1 (PRC1) (Kanehira 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the majority of bladder cancers (Kanehira 2007)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	inhibition of the KIF20B/PRC1 expression or their interaction should be novel therapeutic targets for bladder cancers (Kanehira 2007)

ANIMAL & CELL MODELS