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FLASH GENE
Symbol KERA contributors: - updated : 14-03-2007
HGNC name keratocan
HGNC id 6309
Corresponding disease
CNA2 cornea plana 2
Location 12q21.3-q22      Physical location : 91.444.272 - 91.452.131
Synonym name
  • lumican proteoglycan
    • Synonym symbol(s) SLRR2B, LDC
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text cluster SLRP
    STRUCTURE 7.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningcorneal stroma  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neural crest development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions
  • a N linked glycosylation site (NKSIT motifs) in the LRR region
    • HOMOLOGY
    Homologene
    FAMILY small leucine-rich proteoglycan family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • cornea-specific keratan sulfate proteoglycan involved in maintenance of corneal transparency
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text age morphogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component keratan sulfate proteoglycan
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding collagen fibrils
    cell & other
    REGULATION
    Other regulated by lumican
    ASSOCIATED DISORDERS
    corresponding disease(s) CNA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS