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FLASH GENE
Symbol KERA contributors: - updated : 14-03-2007
HGNC name keratocan
HGNC id 6309
Corresponding disease
CNA2 cornea plana 2
Location 12q21.3-q22      Physical location : 91.444.272 - 91.452.131
Synonym name
  • lumican proteoglycan
  • Synonym symbol(s) SLRR2B, LDC
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text cluster SLRP
    STRUCTURE 7.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Physical map
    HCP30 12q21.33 cytochrome c, somatic pseudogene LOC160420 12q21.33 similar to Makorin 1 FLJ35821 12q21.33 hypothetical protein FLJ35821 DKFZp434N2030 12q21.33 hypothetical protein DKFZp434N2030 KIAA0373 12q21-q22 hypothetical protein DKFZp434N2030 FLJ13615 12q21.33 hypothetical protein FLJ13615 FLJ90492 12q21.33 hypothetical protein FLJ90492 KITLG 12q22 KIT ligand MRPS6P4 12q21 mitochondrial ribosomal protein S6 pseudogene 4 DUSP6 12q21 dual specificity phosphatase 6 TUWD12 12q21.33 TUWD12 CENPC2 12q21.2-q21.33 centromere protein C2, 140kDa GALNT4 12q21.3-q22 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) ATP2B1 12q21-q23 ATPase, Ca++ transporting, plasma membrane 1 MRPL2P1 12q21.33 ATPase, Ca++ transporting, plasma membrane 1 FLJ25378 12q22 hypothetical protein FLJ25378 MGC26598 12q22 hypothetical protein MGC26598 DSPG3 12q21.3-q22 dermatan sulfate proteoglycan 3 KERA 12q22 keratocan LUM 12q21.3-q22 lumican DCN 12q13.2 decorin BTG1 12q22 B-cell translocation gene 1, anti-proliferative LOC387872 12 hypothetical gene supported by BC044741 LOC390351 12 similar to 60S ribosomal protein L21 LOC283388 12q22 similar to guanine nucleotide exchange factor (1B384) EEA1 12q21.31 early endosome antigen 1, 162kD LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningcorneal stroma  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neural crest development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions
  • a N linked glycosylation site (NKSIT motifs) in the LRR region
  • HOMOLOGY
    Homologene
    FAMILY small leucine-rich proteoglycan family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • cornea-specific keratan sulfate proteoglycan involved in maintenance of corneal transparency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text age morphogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component keratan sulfate proteoglycan
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding collagen fibrils
    cell & other
    REGULATION
    Other regulated by lumican
    ASSOCIATED DISORDERS
    corresponding disease(s) CNA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS