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FLASH GENE
Symbol KERA contributors: - updated : 14-03-2007
HGNC name keratocan
HGNC id 6309
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions
  • a N linked glycosylation site (NKSIT motifs) in the LRR region
  • HOMOLOGY
    Homologene
    FAMILY small leucine-rich proteoglycan family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • cornea-specific keratan sulfate proteoglycan involved in maintenance of corneal transparency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text age morphogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component keratan sulfate proteoglycan
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding collagen fibrils
    cell & other
    REGULATION
    Other regulated by lumican
    ASSOCIATED DISORDERS
    corresponding disease(s) CNA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS