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FLASH GENE
Symbol KERA contributors: - updated : 14-03-2007
HGNC name keratocan
HGNC id 6309
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningcorneal stroma  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neural crest development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions
  • a N linked glycosylation site (NKSIT motifs) in the LRR region
    • HOMOLOGY
    Homologene
    FAMILY small leucine-rich proteoglycan family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • cornea-specific keratan sulfate proteoglycan involved in maintenance of corneal transparency
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text age morphogenesis
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component keratan sulfate proteoglycan
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding collagen fibrils
    cell & other
    REGULATION
    Other regulated by lumican
    ASSOCIATED DISORDERS
    corresponding disease(s) CNA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS