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Symbol JAM3 contributors: shn/npt/pgu - updated : 24-08-2020
HGNC name junctional adhesion molecule 3
HGNC id 15532
Corresponding disease
BCPMG2 band-like calcification with simplified gyration and polymicrogyria 2
DEL11QD chromosome 11q distal deletion syndrome
Location 11q25      Physical location : 133.938.819 - 134.021.649
Synonym name junctional adhesion molecule C
Synonym symbol(s) JAMC, JAM-C, FLJ14529, JAM-2 , JAM-3, FLJ14529
TYPE functioning gene
STRUCTURE 82.93 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D11S4112 - D11S4098 - JAM3 - D11S4125 - D11S2359 - qter
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3675 43 355 . localized to Schwann cells at junctions between adjoining myelin end loops . peripheral and sural nerves . tight junctions of cultured hfRPE cells and adult native RPE 2009 19060272
8 - 3612 - 259 - 2009 19060272
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Digestiveintestine   highly Homo sapiens
Lymphoid/Immunelymphatic vessel   highly Homo sapiensAdult
Nervousbrainforebraincerebral lobeoccipital lobehighly
 brainforebraincerebral lobefrontal lobehighly
 brainhindbrainmedulla oblongata highly
 brainforebraincerebral cortex highly
 brainhindbraincerebellum highly
 brain   highly Homo sapiens
 brainforebraincerebral lobetemporal lobehighly
Reproductivefemale systemplacenta  highly Homo sapiens
Urinarykidney   highly Homo sapiens
Visualeyeretina  highly Homo sapiens
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiensAdult
Cardiovascularendothelial cell Homo sapiens
Digestiveepithelial cell Homo sapiens
Lymphoid/ImmuneB cell Homo sapiensAdult
NervousSchawnn cell Homo sapiens
Reproductivegerm cell Homo sapiens
cell lineage
cell lines endothelial cells HAEC and HUVEC
physiological period embryo, fetal, pregnancy
Text placenta, heart (outflow tract), neural tube, eye, moderately in imbilical cord
  • a 30 aa signal peptide of 3 kda
  • two Ig-like folds (one a V type and the other a C2 type containing six cysteines)
  • two potential N glycosylation sites
  • C terminal binding motif for PDZ domain
  • a phosphorylation site
  • conjugated GlycoP
    interspecies ortholog to Jam3, rattus norvegicus
    ortholog to Jam3, Mus msculus
    ortholog to JAM3, Pan troglodytes
    ortholog to jam3, Danio rerio
    intraspecies homolog to JAM2, JAM1
  • immunoglobulin superfamily
  • member of the junctional adhesion molecule (JAM) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    plasma membrane,junction,desmosome
  • integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles
  • single-pass type I membrane protein
  • co-localized with TJP1 to adherens-like junctions
  • localizes to the apically localized tight junctions (TJs) between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesions
  • basic FUNCTION
  • mediating interaction of JAM2 with T, NK and dendritic cells
  • may participating in cell-cell adhesion distinct from tight junctions
  • playing an important role in maintaining the integrity and function of myelinated peripheral nerves
  • participating in the later steps of the leukoendothelial adhesion cascade
  • may playing a role in desmosomal structure/function
  • a possible role in endothelial cell polarity
  • required for the differentiation of round spermatids into spermatozoa
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • required for maturation and polarization of cone photoreceptors cells
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • a component of the autotypic junctional attachments of Schwann cells, plays an important role in maintaining the integrity and function of myelinated peripheral nerves
  • regulates unidirectional monocyte transendothelial migration in inflammation
  • important for tight junction formation and polarization of human retinal pigment epithelium cells and promotes the basal-to-apical transmigration of granulocytes through the hfRPE
  • regulate transmigration of granulocytes in retinal pigment epithelium, and it might play a role in retinal inflammatory processes
  • plays a critical role in the initiation of inflammatory pathologies of the retina
  • regulates polarized transendothelial migration of neutrophils
  • is a novel surface marker for neural stem cells
  • JAMB and JAMC are potentially essential for vertebrate myocyte fusion
  • role of JAM2, JAM3 in progression of gastric adenocarcinoma
  • play critical roles during development and in immune responses
  • is involved in germ cell polarity and acrosome formation
  • plays a pivotal role in neutrophil transmigration into tissues
  • may be a novel tumor suppressor gene with epigenetic reduction in colorectal cancer (CRC)
  • dynamic JAM3 trafficking and degradation are necessary for junctional remodelling during cell migration and angiogenesis
    PHYSIOLOGICAL PROCESS inflammation , nervous system
    a component
    small molecule
  • JAM1
  • interactions with JAM2 and JAM3 are essential for development of cutaneous inflammation
  • JAM2 is a high affinity JAM3 ligand
  • cell polarity protein PAR-3
  • beta2-integrin Mac-1
  • alphaXbeta2, CD11c/CD18
  • functional adhesive interaction between JAM2 and JAM3 is found between human hematopoietic stem and progenitor cells (HSPC) and mesenchymal stem cells
  • JAM3 plays an important role in maintaining KDR expression to promote RPE cell survival under oxidative stress
  • JAM3 interacted with the Golgi reassembly stacking protein of 55 kDa (GORASP2) in developing germ cells
  • cell & other
    corresponding disease(s) DEL11QD , BCPMG2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly elevated in renal carcinoma cells compared with that in renal tubular epithelial cells
    Variant & Polymorphism
    Candidate gene
  • is a new identification tool in B-cell lymphoma diagnosis
  • Marker
  • can be used as a potential noninvasive biomarker for colorectal cancer (CRC) diagnosis
  • Therapy target
    Targeting JAM-C could thus constitute a new therapeutic strategy to prevent lymphoma cells from reaching supportive microenvironments not only in the bone marrow and lymph nodes but also in the spleen
    potential of JAM3 and JAM2 as new targets for the treatment of human gliomas
    novel target gene for the diagnosis and treatment of renal cell carcinoma (RCC)
    reduction of the pro-inflammatory aged neutrophils by blockade of JAM3 has a novel therapeutic potential in sepsis-induced acute lung injury (ALI)
  • JAM-C gene knocked out mice exhibited loss of integrity of the myelin sheath, defective nerve conduction and motor abnormalities
  • JAM3 knockdown caused a delay in the hfRPE cell polarization, and JAM3 inhibition significantly decreased the chemokine-induced transmigration of granulocytes through the hfRPE monolayer