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FLASH GENE
Symbol JAM3 contributors: shn/npt/pgu - updated : 16-12-2009
HGNC name junctional adhesion molecule 3
HGNC id 15532
Corresponding disease
BCPMG2 band-like calcification with simplified gyration and polymicrogyria 2
DEL11QD chromosome 11q distal deletion syndrome
Location 11q25      Physical location : 133.938.819 - 134.021.649
Synonym name junctional adhesion molecule C
Synonym symbol(s) JAMC, JAM-C, FLJ14529, JAM-2 , JAM-3
DNA
TYPE functioning gene
STRUCTURE 82.83 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D11S4112 - D11S4098 - JAM3 - D11S4125 - D11S2359 - qter
Physical map
HNT 11q25 neurotrimin OPCML 11q25 opioid binding protein/cell adhesion molecule-like FLJ25851 11q25 spergen-1 LOC283172 11q25 similar to h2-calponin KIAA1030 11q25 similar to h2-calponin JAM3 11q25 junctional adhesion molecule 3 KIAA0056 11q25 KIAA0056 protein MGC10485 11q25 hypothetical protein MGC10485 THY28 11q25 thymocyte protein thy28 ACAD8 11q25 acyl-Coenzyme A dehydrogenase family, member 8 LOC112937 11q25 hypothetical protein BC011001 FLJ90231 11q25 hypothetical protein FLJ90231 LOC89944 11q25 hypothetical protein BC008326 B3GAT1 11q25 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) LOC341098 11q25 similar to ENSANGP00000020885 LOC390278 11 similar to retinitis pigmentosa GTPase regulator
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3675 43 355 . localized to Schwann cells at junctions between adjoining myelin end loops . peripheral and sural nerves . tight junctions of cultured hfRPE cells and adult native RPE 2009 19060272
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Lymphoid/Immunelymphatic vessel   highly Homo sapiensAdult
Nervousbrainforebraincerebral lobeoccipital lobehighly
 brainforebraincerebral lobefrontal lobehighly
 brainhindbrainmedulla oblongata highly
 brainforebraincerebral cortex highly
 brainhindbraincerebellum highly
 brain   highly Homo sapiens
 brainforebraincerebral lobetemporal lobehighly
 spinal cord   highly
Reproductivefemale systemplacenta  highly Homo sapiens
Urinarykidney   highly Homo sapiens
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiensAdult
Cardiovascularendothelial cell Homo sapiens
Lymphoid/ImmuneB cell Homo sapiensAdult
NervousSchawnn cell Homo sapiens
cell lineage
cell lines endothelial cells HAEC and HUVEC
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta, heart (outflow tract), neural tube, eye, moderately in imbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 30 aa signal peptide of 3 kda
  • two Ig-like folds (one a V type and the other a C2 type containing six cysteines)
  • two potential N glycosylation sites
  • C terminal binding motif for PDZ domain
  • a phosphorylation site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Jam3, rattus norvegicus
    ortholog to Jam3, Mus msculus
    ortholog to JAM3, Pan troglodytes
    ortholog to jam3, Danio rerio
    intraspecies homolog to JAM2, JAM1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • member of the junctional adhesion molecule (JAM) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles
  • single-pass type I membrane protein
  • co-localized with TJP1 to adherens-like junctions
  • localizes to the apically localized tight junctions (TJs) between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesions
  • basic FUNCTION
  • mediating interaction of JAM2 with T, NK and dendritic cells
  • may participating in cell-cell adhesion distinct from tight junctions
  • playing an important role in maintaining the integrity and function of myelinated peripheral nerves
  • participating in the later steps of the leukoendothelial adhesion cascade
  • may playing a role in desmosomal structure/function
  • a possible role in endothelial cell polarity
  • required for the differentiation of round spermatids into spermatozoa
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • required for maturation and polarization of cone photoreceptors cells
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • a component of the autotypic junctional attachments of Schwann cells, plays an important role in maintaining the integrity and function of myelinated peripheral nerves
  • regulates unidirectional monocyte transendothelial migration in inflammation
  • important for tight junction formation and polarization of human retinal pigment epithelium cells and promotes the basal-to-apical transmigration of granulocytes through the hfRPE
  • regulate transmigration of granulocytes in retinal pigment epithelium, and it might play a role in retinal inflammatory processes
  • plays a critical role in the initiation of inflammatory pathologies of the retina
  • regulates polarized transendothelial migration of neutrophils
  • is a novel surface marker for neural stem cells
  • JAMB and JAMC are potentially essential for vertebrate myocyte fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAM1
  • interactions with JAM2 and JAM3 are essential for development of cutaneous inflammation
  • JAM2 is a high affinity JAM3 ligand
  • cell polarity protein PAR-3
  • beta2-integrin Mac-1
  • alphaXbeta2, CD11c/CD18
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL11QD , BCPMG2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • as a new identification tool in B-cell lymphoma diagnosis
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    Targeting JAM-C could thus constitute a new therapeutic strategy to prevent lymphoma cells from reaching supportive microenvironments not only in the bone marrow and lymph nodes but also in the spleen
    cancerbrain 
    potential of JAM3 and JAM2 as new targets for the treatment of human gliomas
    ANIMAL & CELL MODELS
  • JAM-C gene knocked out mice exhibited loss of integrity of the myelin sheath, defective nerve conduction and motor abnormalities
  • JAM3 knockdown caused a delay in the hfRPE cell polarization, and JAM3 inhibition significantly decreased the chemokine-induced transmigration of granulocytes through the hfRPE monolayer