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FLASH GENE
Symbol ITGB2 contributors: mct - updated : 08-03-2012
HGNC name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
HGNC id 6155
Corresponding disease
LAD1 leukocyte adhesion deficiency, type I
Location 21q22.3      Physical location : 46.305.867 - 46.348.753
Synonym name
  • integrin beta-2
  • lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
  • lymphocyte function common antigen 1,beta chain common subunit, identified by monoclonal antibodies MHM23, M232, CLB54
  • complement receptor C3 subunit beta
  • cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit precursor)
  • complement receptor C3 subunit beta
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • Synonym symbol(s) CD18, LFA1B, LAD, MF17, LCAMB, LFA-1, MAC-1, MFI7
    DNA
    TYPE functioning gene
    STRUCTURE 35.10 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    ICOSL 21q22.3 inducible T-cell co-stimulator ligand DNMT3L 21q22.3 DNA (cytosine-5-)-methyltransferase 3-like AIRE 21q22.3 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) PFKL 21q22.3 phosphofructokinase, liver C21orf2 21q22.3 chromosome 21 open reading frame 2 TRPM2 21q22.3 transient receptor potential cation channel, subfamily M, member 2 LRRC3 21q22.3 leucine-rich repeat-containing 3 C21orf29 21q22.3 chromosome 21 open reading frame 29 C21orf90 21q22.1 chromosome 21 open reading frame 90 KRTAP10-10 21q22.3 keratin associated protein 10-10 KRTAP12-2 21q22.3 keratin associated protein 12-2 IMMTP 21q22.3 inner membrane protein, mitochondrial (mitofilin) pseudogene KRTAP12-1 21q22.3 keratin associated protein 12-1 UBE2G2 21q22.3 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) SMT3H1 21q22.3 SMT3 suppressor of mif two 3 homolog 1 (yeast) PTTG1IP 21q22.3 pituitary tumor-transforming 1 interacting protein ITGB2 21q22.3 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) C21orf69 21q22.3 chromosome 21 open reading frame 69 C21orf67 21q22.3 chromosome 21 open reading frame 67 C21orf70 21q22.3 chromosome 21 open reading frame 70 LOC391283 21 similar to interspersed repeat antigen, putative C21orf122 21q22.3 chromosome 21 open reading frame 122 ADARB1 21q22.3 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) C21orf89 21q22.1 chromosome 21 open reading frame 89 C21orf80 21q22.3 chromosome 21 open reading frame 80 C21orf86 21q22.1 chromosome 21 open reading frame 86 C21orf93 21q22.1 chromosome 21 open reading frame 93 LOC388830 21 similar to PRED59 COL18A1 21q22.3 collagen, type XVIII, alpha 1
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2977 - 769 - 1997 8995416
    16 - 2932 - 769 - 1997 8995416
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   lowly
    Lymphoid/Immunespleen   predominantly
     thymus   predominantly
     tonsils   highly
    Reproductivefemale systemplacenta  lowly
     male systemprostate  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  lowly
    Connective   moderately
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA-like domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Itgb2 (81.38 pc)
    homolog to murine Itgb2 (82.05 pc)
    Homologene
    FAMILY
  • integrin beta chain family
  • CATEGORY adhesion , immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • regulates T cell activation and signal transduction through the immunological synapse
  • function of ITGB2 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD8+ T cell activation
  • unique role in T cell Ca2+ signaling and ITGB2-dependent Ca2+ entry proceeds via a mechanism separate from store-operated Ca2+ entry
  • ITGB2 signaling is required for the generation of central memory CD8(+) T cells in priming phase
  • plays a key role in regulating neutrophil recruitment, CXCL2 formation and tissue injury in the pancreas
  • mediating T cell migration, essential for immune surveillance and response
  • pivotal role of neutrophil ITGB2 and ROS in this process provides a potential target for modulating immune responses
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • common constituent of LFA-1, Mac-1 and p150, 95 antigens
  • dimerizing with ITGAL, ITGAM, ITGAX (see symbols)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ILK, GNB2L1, ITGB1BP, ITGAL, ITGAM, ITGAX
  • SPN interacts with BSG and ITGB2 in two distinct but similarly reorganized complexes
  • interacting with RAP1A (mediates ITGB2 activation and ITGB2-mediated adhesion)
  • interacting with calpain 2, that controls turnover of ITGB2 adhesions on migrating T lymphocytes
  • interaction with CTSZ (cysteine carboxypeptidase, that is involved in the regulation of T cell migration by interaction with ITGB2)
  • FERMT3 is a key lymphocyte function-associated antigen-1 (ITGB2) coactivator
  • interacting with CYTH1 (regulates adhesion and the transendothelial migration of monocytes, dendritic cells and T lymphocytes through activation of ITGB2)
  • interacting with ANGPT2 (is a novel, endothelial-derived regulator of myeloid cell infiltration that modulates ITGB2-mediated adhesion in a paracrine manner)
  • interacting with TIAM1 (TCR-induced activation of ITGB2 involves signaling through TIAM1)
  • FERMT3 is enriched within focal clusters of high-affinity ITGB2, which promoted physical linkage with ORAI1
  • binding of ITGB2 to ICAM1 has a downstream effect in the recruitment of kindlin 3 to the membrane that is PH-dependent
  • cell & other
  • unstimulated and activated endothelial cells
  • REGULATION
    Other CTSZ cleavage of ITGB2 regulates talin-binding and ITGB2 affinity in T cells
    regulation of ITGB2 activity allows dendritic cells to actively control antigen-driven T-cell proliferation and effective immune responses
    ASSOCIATED DISORDERS
    corresponding disease(s) LAD1
    related resource ITGB2base: Mutation registry for Leucosyte adhesion deficiency I (LAD-I)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestive  
    targeting ITGB2 may be a useful approach to protect against pathological inflammation in the pancreas
    ANIMAL & CELL MODELS