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FLASH GENE
Symbol ITGB2 contributors: mct - updated : 08-03-2012
HGNC name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
HGNC id 6155
Corresponding disease
LAD1 leukocyte adhesion deficiency, type I
Location 21q22.3      Physical location : 46.305.867 - 46.348.753
Synonym name
  • integrin beta-2
  • lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
  • lymphocyte function common antigen 1,beta chain common subunit, identified by monoclonal antibodies MHM23, M232, CLB54
  • complement receptor C3 subunit beta
  • cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit precursor)
  • complement receptor C3 subunit beta
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
    • Synonym symbol(s) CD18, LFA1B, LAD, MF17, LCAMB, LFA-1, MAC-1, MFI7
    DNA
    TYPE functioning gene
    STRUCTURE 35.10 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2977 - 769 - 1997 8995416
    16 - 2932 - 769 - 1997 8995416
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   lowly
    Lymphoid/Immunespleen   predominantly
     thymus   predominantly
     tonsils   highly
    Reproductivefemale systemplacenta  lowly
     male systemprostate  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  lowly
    Connective   moderately
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA-like domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Itgb2 (81.38 pc)
    homolog to murine Itgb2 (82.05 pc)
    Homologene
    FAMILY
  • integrin beta chain family
    • CATEGORY adhesion , immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • regulates T cell activation and signal transduction through the immunological synapse
  • function of ITGB2 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD8+ T cell activation
  • unique role in T cell Ca2+ signaling and ITGB2-dependent Ca2+ entry proceeds via a mechanism separate from store-operated Ca2+ entry
  • ITGB2 signaling is required for the generation of central memory CD8(+) T cells in priming phase
  • controls many functions of T lymphocytes and is particularly essential during lymphocyte migration from blood into tissues
  • plays a key role in regulating neutrophil recruitment, CXCL2 formation and tissue injury in the pancreas
  • mediating T cell migration, essential for immune surveillance and response
  • pivotal role of neutrophil ITGB2 and ROS in this process provides a potential target for modulating immune responses
    • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • common constituent of LFA-1, Mac-1 and p150, 95 antigens
  • dimerizing with ITGAL, ITGAM, ITGAX (see symbols)
  • ITGB2/LCK/ZAP70 complex is in position to initiate the rapid adhesion strengthening and migration necessary for T-lymphocyte responses when stimulated vasculature is encountered at sites of infection or injury
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ILK, GNB2L1, ITGB1BP, ITGAL, ITGAM, ITGAX
  • SPN interacts with BSG and ITGB2 in two distinct but similarly reorganized complexes
  • interacting with RAP1A (mediates ITGB2 activation and ITGB2-mediated adhesion)
  • interacting with calpain 2, that controls turnover of ITGB2 adhesions on migrating T lymphocytes
  • is constitutively associated with the protein tyrosine kinases LCK and ZAP70 (pMID: 21200022)
  • interaction with CTSZ (cysteine carboxypeptidase, that is involved in the regulation of T cell migration by interaction with ITGB2)
  • FERMT3 is a key lymphocyte function-associated antigen-1 (ITGB2) coactivator
  • interacting with CYTH1 (regulates adhesion and the transendothelial migration of monocytes, dendritic cells and T lymphocytes through activation of ITGB2)
  • interacting with ANGPT2 (is a novel, endothelial-derived regulator of myeloid cell infiltration that modulates ITGB2-mediated adhesion in a paracrine manner)
  • interacting with TIAM1 (TCR-induced activation of ITGB2 involves signaling through TIAM1)
  • FERMT3 is enriched within focal clusters of high-affinity ITGB2, which promoted physical linkage with ORAI1
  • binding of ITGB2 to ICAM1 has a downstream effect in the recruitment of kindlin 3 to the membrane that is PH-dependent
  • FOLR2 is a novel ITGAM/ITGB2 regulator for trafficking and homing of a subset of macrophages on collagen
    • cell & other
  • unstimulated and activated endothelial cells
    • REGULATION
    Other CTSZ cleavage of ITGB2 regulates talin-binding and ITGB2 affinity in T cells
    regulation of ITGB2 activity allows dendritic cells to actively control antigen-driven T-cell proliferation and effective immune responses
    ASSOCIATED DISORDERS
    corresponding disease(s) LAD1
    related resource ITGB2base: Mutation registry for Leucosyte adhesion deficiency I (LAD-I)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestive  
    targeting ITGB2 may be a useful approach to protect against pathological inflammation in the pancreas
    ANIMAL & CELL MODELS