| 1 | FOLR2, ITGAM, ITGB2
|
| Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.
|
| Machacek C, Supper V, Leksa V, Mitulovic G, Spittler A, Drbal K, Suchanek M, Ohradanova-Repic A, Stockinger H.
|
| J Immunol 197(6):2229-38. doi: 10.4049/jimmunol.1501878. Epub 2016 Aug 17.
2016
|
| 2 | FERMT3, ITGB2
|
| The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migration.
|
| Hart R, Stanley P, Chakravarty P, Hogg N.
|
| J Biol Chem 288(21):14852-62. doi: 10.1074/jbc.M112.434621. Epub 2013 Apr 17.
2013
|
| 3 | ITGB2
|
| A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
|
| Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW, Ulfman LH, Leenen LP, Pickkers P, Koenderman L.
|
| J Clin Invest 122(1):327-36. doi: 10.1172/JCI57990. Epub 2011 Dec 12.
2012
|
| 4 | FERMT3, ITGB2
|
| Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation.
|
| Dixit N, Kim MH, Rossaint J, Yamayoshi I, Zarbock A, Simon SI.
|
| J Immunol 189(12):5954-64. doi: 10.4049/jimmunol.1201638. Epub 2012 Nov 9.
2012
|
| 5 | ITGB2, LAD1
|
| A novel 3' splice-site mutation and a novel gross deletion in leukocyte adhesion deficiency (LAD)-1.
|
| Bernard Cher TH, Chan HS, Klein GF, Jabkowski J, Schadenböck-Kranzl G, Zach O, Roca X, Law SK.
|
| Biochem Biophys Res Commun 404(4):1099-104. Epub 2010 Dec 31.
2011
|
| 6 | FERMT3, ITGB2, LAD3
|
| Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.
|
| Feigelson SW, Grabovsky V, Manevich-Mendelson E, Pasvolsky R, Shulman Z, Shinder V, Klein E, Etzioni A, Aker M, Alon R.
|
| Blood 117(26):7042-52. Epub 2011 May 2.
2011
|
| 7 | ITGB2, TIAM1
|
| TCR-induced activation of LFA-1 involves signaling through Tiam1.
|
| Grönholm M, Jahan F, Marchesan S, Karvonen U, Aatonen M, Narumanchi S, Gahmberg CG.
|
| J Immunol 187(7):3613-9. Epub 2011 Aug 29.
2011
|
| 8 | ANGPT2, ITGB2
|
| Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.
|
| Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.
|
| Blood 118(18):5050-9. Epub 2011 Aug 25.
2011
|
| 9 | CYTH1, ITGB2
|
| Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.
|
| El azreq MA, Bourgoin SG.
|
| Mol Immunol 48(12-13):1408-16. Epub 2011 Apr 20.
2011
|
| 10 | CTSZ, ITGAL, ITGB2
|
| Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.
|
| Jevnikar Z, Obermajer N, Doljak B, Turk S, Gobec S, Svajger U, Hailfinger S, Thome M, Kos J.
|
| J Leukoc Biol 90(1):99-109. Epub 2011 Mar 31. 2011
|
| 11 | ITGB2
|
| Lymphocyte function antigen-1 regulates neutrophil recruitment and tissue damage in acute pancreatitis.
|
| Awla D, Abdulla A, Zhang S, Roller J, Menger MD, Regnér S, Thorlacius H.
|
| Br J Pharmacol 163(2):413-23. doi: 10.1111/j.1476-5381.2011.01225.x.
2011
|
| 12 | ITGB2, LCK, ZAP70
|
| The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes.
|
| Evans R, Lellouch AC, Svensson L, McDowall A, Hogg N.
|
| Blood 117(12):3331-42. doi: 10.1182/blood-2010-06-289140. Epub 2011 Jan 3.
2011
|
| 13 | CAPN2, ITGAL, ITGB2
|
| Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes.
|
| Svensson L, McDowall A, Giles KM, Stanley P, Feske S, Hogg N.
|
| PLoS One 5(11):e15090. 2010
|
| 14 | ITGB2, RAP1A
|
| Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.
|
| Li L, Kim J, Boussiotis VA.
|
| Cell Immunol 266(1):7-13. Epub 2010 Sep 22.
2010
|
| 15 | ITGB2
|
| LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R.
|
| Ye Z, Shi M, Xu S, Xiang J.
|
| Mol Immunol 47(14):2411-21. Epub 2010 May 31.
2010
|
| 16 | ITGB2
|
| LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.
|
| Balkow S, Heinz S, Schmidbauer P, Kolanus W, Holzmann B, Grabbe S, Laschinger M.
|
| Blood 116(11):1885-94. Epub 2010 Jun 8.
2010
|
| 17 | ITGAL, ITGB2
|
| Possible acceleration of regression by antibiotic treatment in benign cephalic histiocytosis with infiltration of CD11a/CD11c+ macrophages.
|
| Quist SR, Weidling H, Franke I, Bonnekoh B, Gollnick HP.
|
| Acta Derm Venereol 90(4):429-30. doi: 10.2340/00015555-0872. No abstract available.
2010
|
| 18 | ITGAL, ITGB2
|
| A transmembrane polar interaction is involved in the functional regulation of integrin alpha L beta 2.
|
| Vararattanavech A, Chng CP, Parthasarathy K, Tang XY, Torres J, Tan SM.
|
| J Mol Biol 398(4):569-83. doi: 10.1016/j.jmb.2010.03.027. Epub 2010 Mar 23.
2010
|
| 19 | CTSZ, ITGB2
|
| Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding.
|
| Jevnikar Z, Obermajer N, Pecar-Fonović U, Karaoglanovic-Carmona A, Kos J.
|
| Eur J Immunol 39(11):3217-27.
2009
|
| 20 | ITGB2
|
| LFA-1-dependent Ca2+ entry following suboptimal T cell receptor triggering proceeds without mobilization of intracellular Ca2+.
|
| Kim K, Wang L, Hwang I.
|
| J Biol Chem 284(33):22149-54. Epub 2009 Jun 19.
2009
|
| 21 | ITGB2
|
| LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.
|
| Li D, Molldrem JJ, Ma Q.
|
| J Biol Chem 284(31):21001-10. Epub 2009 May 29.
2009
|
| 22 | BSG, ITGB2, SPN
|
| LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147.
|
| Khunkaewla P, Schiller HB, Paster W, Leksa V, Cermák L, Andera L, Horejsí V, Stockinger H.
|
| Mol Immunol 45(6):1703-11. Epub 2007 Nov 9.
2008
|
| 23 | ITGB2
|
| Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications.
|
| Schymeinsky J, Mócsai A, Walzog B.
|
| Thromb Haemost 98(2):262-73. Review.
2007
|
| 24 | HCK,ITGAM,ITGB2
|
| Selective recruitment of src family kinase Hck by leukocyte integrin alphaMbeta2 but not alphaLbeta2 or alphaXbeta2.
|
| Tang RH, Law SK, Tan SM.
|
| FEBS Lett 580(18):4435-42. Epub 2006 Jul 13. 2006
|
| 25 | ICAM1, ITGB2
|
| Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium.
|
| Wu Y, Ip JE, Huang J, Zhang L, Matsushita K, Liew CC, Pratt RE, Dzau VJ.
|
| Circ Res 99(3):315-22. Epub 2006 Jul 6. 2006
|
| 26 | ITGB2, ITGAL, ICAM1
|
| Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis.
|
| Kawamura A, Miura S, Murayama T, Iwata A, Zhang B, Nishikawa H, Tsuchiya Y, Matsuo K, Tsuji E, Saku K.
|
| Circ J 68(1):6-10. 2004
|
| 27 | ITGB2, RANBP9
|
| RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.
|
| Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, Fabbri M, Pardi R, Bianchi E.
|
| J Biol Chem 279(13):13027-34. Epub 2004 Jan 13. 2004
|
| 28 | ITGAM, BCAP31, ITGB2
|
| Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils.
|
| Zen K, Utech M, Liu Y, Soto I, Nusrat A, Parkos CA.
|
| J Biol Chem 279(43):44924-30. Epub 2004 Aug 4. 2004
|
| 29 | LAD1, ITGB2
|
| Genetic analysis of patients with leukocyte adhesion deficiency: genomic sequencing reveals otherwise undetectable mutations.
|
| Roos D, Meischl C, de Boer M, Simsek S, Weening RS, Sanal O, Tezcan I, Gungor T, Law SK.
|
| Exp Hematol 30(3):252-61. 2002
|
| 30 | ICAM1, ITGB2
|
| Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion.
|
| Jun CD, Shimaoka M, Carman CV, Takagi J, Springer TA.
|
| Proc Natl Acad Sci U S A 98(12):6830-5. 2001
|
| 31 | ITGB2
|
| A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.
|
| Hogg N, et al.
|
| J Clin Invest 103(1):97-106. 1999
|
| 32 | ADARB1, C21orf33, CABIN1, COL18A1, COL6A1, COL6A2, CSTB, ILVBL, ITGB2, KRTAP12-1, PDXK, PFKL, PGA1, PRMT2, S100B, TRAPPC10, TRPM2, UBE2G2
|
| Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.
|
| Wiltshire T, Pletcher M, Cole SE, Villanueva M, Birren B, Lehoczky J, Dewar K, Reeves RH.
|
| Genome Res 9(12):1214-22 1999
|
| 33 | ITGAL, ITGB2, TLN1
|
| cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1.
|
| Mizuno T, et al.
|
| J Biol Chem 272 : 1156-1163. 1997
|
| 34 | ITGB2, LAD1
|
| Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component.
|
| Motoki K, Megahed M, LaForgia S, Uitto J.
|
| Genomics 39 : 323-330. 1997
|
| 35 | CYTH1, ITGB2
|
| Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.
|
| Kolanus W, et al.
|
| Cell 86 : 233-242. 1996
|
| 36 | ITGB2
|
| Investigation of the polymorphic AvaII site by a PCR-based assay at the human CD18 gene locus.
|
| Mastuura S, et al.
|
| Hum Genet 93 : 721. 1994
|
| 37 | ETS2, HMGN1, ITGB2, COL6A1
|
| DNA polymorphisms in the 3' untranslated region of genes on human chromosome 21.
|
| Avramopoulos D, et al.
|
| Genomics 15 : 98-102. 1993
|
| 38 | LAD1, ITGB2
|
| A point mutation associated with leukocyte adhesion deficiency type 1 of moderate severity.
|
| Back AL, et al.
|
| Biochem Biophys Res Commun 193 : 912-918. 1993
|
| 39 | ITGB2, LAD1
|
| Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta2 integrins.
|
| Nelson C, et al.
|
| J Biol Chem 267 : 3351-3357. 1992
|
| 40 | ITGB2, LAD1
|
| An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency.
|
| Sligh JE, et al.
|
| J Biol Chem 267 : 714-718. 1992
|
| 41 | ITGB2
|
| Identification of two molecular defects in a child with leukocyte adherence deficiency.
|
| Back AL, et al.
|
| J Biol Chem 267 : 5482-5487. 1992
|
| 42 | ITGB2, LAD1
|
| Leukocyte adhesion deficiency : identification of novel mutations in two Japanese Patients with a severe form.
|
| Matsuura S, et al.
|
| Biochem Biophys Res Commun 184 : 1460-1467. 1992
|
| 43 | ITGB2, LAD1
|
| Molecular basis for a severe case of leucocyte adhesion deficiency.
|
| Corbi AL, et al.
|
| Eur J immunol 22 : 1877-1881. 1992
|
| 44 | ITGB2
|
| Linkage analysis of CD18 and D21S113 on chromosome 21.
|
| Petersen MB, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1059. 1989
|
| 45 | ITGB2
|
| Isolation of genes encoded by human chromosome 21.
|
| Stewart GD, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1086. 1989
|
| 46 | ITGB2
|
| Regional localization of CD18, the §-subunit of the cell surface adhesion molecule LFA-1, on human chromosome 21 by in situ hybridization.
|
| Solomon E, et al.
|
| Ann Hum Genet 52 : 123-128. 1988
|
| 47 | ITGAL, ITGAM, ITGAX, ITGB2
|
| Chromosomal location of the genes encoding the leucocyte adhesion receptors LFA-1, Mac-1 and p150,95.
|
| Corbi AL, et al.
|
| J Exp Med 167 : 1597-1607. 1988
|
| 48 | ITGB2
|
| Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency.
|
| Kishimoto TK, et al.
|
| Cell 50 : 193-202. 1987
|
| 49 | ITGAL, PTPRC, ITGB2
|
| Chromosomal assignments of genes coding for human leucocyte common antigen, T-200, and lymphocyte function-associated antigen 1, LFA-1 beta subunit.
|
| Akao Y, et al.
|
| Somat Cell Mol Genet 13 : 273-278. 1987
|
| 50 | ITGB2
|
| Genetic assignment of GP90, leukocyte adhesion glycoprotein to human chromosome 21.
|
| Suomalainen HA, et al.
|
| Somat Cell Mol Genet 12 : 297-302. 1986
|
| 51 | ITGB2
|
| GP90 (Leu-CAM antigen) is coded for by genes on chromosome 21.
|
| Suomalainen HA, et al.
|
| (HGM8) Cytogenet Cell Genet 40 : 755. 1985
|
| 52 | ITGB2, B3GAT1
|
| Chromosomal assignment of genes coding for human cell surface antigens with mouse/human lymphocyte hybrids.
|
| Schrder J, et al.
|
| (HGM7) Cytogenet Cell Genet 37 : 577-578. 1984
|