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FLASH GENE
Symbol IL3 contributors: mct - updated : 02-03-2017
HGNC name interleukin 3 (colony-stimulating factor, multiple)
HGNC id 6011
Corresponding disease
IL3 leukemia, acute, lymphoblastic, preB cell
Location 5q31.1      Physical location : 131.396.346 - 131.398.896
Synonym symbol(s) MU-CSF, IL-3, MCGF, MGC79398, MGC79399, MULTI-CSF, PSF
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 2.55 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see IRF1 ,CSF1R
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 924 - 152 - 1997 9381178
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Il3
ortholog to C.elegans to8a9.5
Homologene
FAMILY interleukin family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • colony-stimulating factor (multilineage)
  • survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1, AKT2)
  • IL3 and KITLG have synergistic effects with EPO on the proliferation, differentiation and apoptosis of erythroid progenitors
  • induces a PIM1-dependent antiapoptotic pathway in primary human basophils
  • strong regulator of hematopoiesis, also potentially playing an important role in inhibition of TNF-alpha-induced bone resorption
  • promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis
  • cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells
  • irreversibly inhibits TNFRSF11A expression that results in inhibition of important signaling molecules induced by TNFSF11
  • required for maintenance of many hematopoietic cell lines, such as BaF3
  • is an important cytokine that regulates hematopoiesis
  • in a dose-dependent manner increases osteoblast differentiation and matrix mineralization in human mesenchymal stem cells (MSCs)
  • has a potential as an anabolic agent for stimulation of bone formation in important bone diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text regulating the proliferation and differentiation of early hematopoietic/lymphoid stem cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOHH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway
  • interacting with XBP1 (the proper transcriptional and splicing regulation of XBP1 by IL3 signaling is important in homeostasis of hematopoietic cells)
  • activates BMP2 signaling which may lead to increased synthesis of bone matrix
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IL3
    Susceptibility
  • rheumatoid arthritis
  • to malaria attacks
  • Variant & Polymorphism SNP
  • IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect against malaria attacks (
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    therapeutic potential for bone formation in important bone diseases
    ANIMAL & CELL MODELS
    mice with expression of IL3 show motor neuron disease with several features of human amyotrophic lateral sclerosis and progressive muscular atrophy.These symptoms are associated with a severe autoimmune reaction against spiral cord motor neurons