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FLASH GENE

Symbol

IL3

contributors: mct - updated : 02-03-2017

HGNC name	interleukin 3 (colony-stimulating factor, multiple)
HGNC id	6011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IL3 leukemia, acute, lymphoblastic, preB cell
Location	5q31.1      Physical location : 131.396.346 - 131.398.896
Synonym symbol(s)	MU-CSF, IL-3, MCGF, MGC79398, MGC79399, MULTI-CSF, PSF

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	2.55 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see IRF1 ,CSF1R

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000588 5 - 924 - 152 - 1997 9381178

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cells

System Cell Pubmed Species Stage Rna symbol   mast cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine Il3
	ortholog to C.elegans to8a9.5

Homologene

FAMILY

interleukin family

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	colony-stimulating factor (multilineage)
	survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1, AKT2)
	IL3 and KITLG have synergistic effects with EPO on the proliferation, differentiation and apoptosis of erythroid progenitors
	induces a PIM1-dependent antiapoptotic pathway in primary human basophils
	strong regulator of hematopoiesis, also potentially playing an important role in inhibition of TNF-alpha-induced bone resorption
	promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis
	cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells
	irreversibly inhibits TNFRSF11A expression that results in inhibition of important signaling molecules induced by TNFSF11
	required for maintenance of many hematopoietic cell lines, such as BaF3
	is an important cytokine that regulates hematopoiesis
	in a dose-dependent manner increases osteoblast differentiation and matrix mineralization in human mesenchymal stem cells (MSCs)
	has a potential as an anabolic agent for stimulation of bone formation in important bone diseases

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

text	regulating the proliferation and differentiation of early hematopoietic/lymphoid stem cells

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RHOHH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway
	interacting with XBP1 (the proper transcriptional and splicing regulation of XBP1 by IL3 signaling is important in homeostasis of hematopoietic cells)
	activates BMP2 signaling which may lead to increased synthesis of bone matrix

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IL3

Susceptibility

rheumatoid arthritis to malaria attacks

Variant & Polymorphism SNP	IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect against malaria attacks (

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone   therapeutic potential for bone formation in important bone diseases

ANIMAL & CELL MODELS

mice with expression of IL3 show motor neuron disease with several features of human amyotrophic lateral sclerosis and progressive muscular atrophy.These symptoms are associated with a severe autoimmune reaction against spiral cord motor neurons