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FLASH GENE
Symbol IL3 contributors: mct - updated : 02-03-2017
HGNC name interleukin 3 (colony-stimulating factor, multiple)
HGNC id 6011
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 2.55 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see IRF1 ,CSF1R
Physical map
LOC133629 5q31.1 similar to ribosomal protein L11 LOC133628 5q31.1 similar to splicing factor 4 isoform a; RNA-binding protein HINT1 5q31.2 histidine triad nucleotide binding protein 1 LOC90624 5q31.1 hypothetical protein LOC90624 SPEC2 5q31 hypothetical protein LOC90624 PDZGEF2 5q31.1 PDZ domain containing guanine nucleotide exchange factor (GEF) 2 ACTBP4 5q23.3 actin, beta pseudogene 4 FACL6 5q31 fatty-acid-Coenzyme A ligase, long-chain 6 IL3 5q31.1 interleukin 3 (colony-stimulating factor, multiple) CSF2 5q31.1 colony stimulating factor 2 (granulocyte-macrophage) LOC389325 5 LOC389325 P4HA2 5q31.1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II RIL 5q31.1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II SLC22A4 5q31.2 solute carrier family 22 (organic cation transporter), member 4 SLC22A5 5q31.1-q32 solute carrier family 22 (organic cation transporter), member 5 LOC389326 5 hypothetical gene supported by AK096941; AK128882 IRF1 5q31.1 interferon regulatory factor 1 IL5 5q31.1 interleukin 5 (colony-stimulating factor, eosinophil) RAD50 5q31 RAD50 homolog (S. cerevisiae) IL13 5q31.1 interleukin 13 IL4 5q31.1 interleukin 4 KIF3A 5q31 kinesin family member 3A SEPT8 5q31 kinesin family member 3A LOC134548 5q31.1 hypothetical protein LOC134548 APXL2 5q31.1 hypothetical protein LOC134548 GDF9 5q31.1 growth differentiation factor 9 QP-C 5q31.1 low molecular mass ubiquinone-binding protein (9.5kD) LEAP-2 5q31.1 liver-expressed antimicrobial peptide 2 AF5Q31 5q31 liver-expressed antimicrobial peptide 2 LOC389327 5 hypothetical gene supported by AK129671 LOC391832 5 similar to putative nucleic acid binding protein RY-1 FLJ20094 5q31.1 hypothetical protein FLJ20094
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 924 - 152 - 1997 9381178
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Il3
ortholog to C.elegans to8a9.5
Homologene
FAMILY interleukin family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • colony-stimulating factor (multilineage)
  • survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1, AKT2)
  • IL3 and KITLG have synergistic effects with EPO on the proliferation, differentiation and apoptosis of erythroid progenitors
  • induces a PIM1-dependent antiapoptotic pathway in primary human basophils
  • strong regulator of hematopoiesis, also potentially playing an important role in inhibition of TNF-alpha-induced bone resorption
  • promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis
  • cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells
  • irreversibly inhibits TNFRSF11A expression that results in inhibition of important signaling molecules induced by TNFSF11
  • required for maintenance of many hematopoietic cell lines, such as BaF3
  • is an important cytokine that regulates hematopoiesis
  • in a dose-dependent manner increases osteoblast differentiation and matrix mineralization in human mesenchymal stem cells (MSCs)
  • has a potential as an anabolic agent for stimulation of bone formation in important bone diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text regulating the proliferation and differentiation of early hematopoietic/lymphoid stem cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOHH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway
  • interacting with XBP1 (the proper transcriptional and splicing regulation of XBP1 by IL3 signaling is important in homeostasis of hematopoietic cells)
  • activates BMP2 signaling which may lead to increased synthesis of bone matrix
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IL3
    Susceptibility
  • rheumatoid arthritis
  • to malaria attacks
  • Variant & Polymorphism SNP
  • IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect against malaria attacks (
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    therapeutic potential for bone formation in important bone diseases
    ANIMAL & CELL MODELS
    mice with expression of IL3 show motor neuron disease with several features of human amyotrophic lateral sclerosis and progressive muscular atrophy.These symptoms are associated with a severe autoimmune reaction against spiral cord motor neurons