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FLASH GENE

Symbol

IL3

contributors: mct - updated : 02-03-2017

HGNC name	interleukin 3 (colony-stimulating factor, multiple)
HGNC id	6011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IL3

Susceptibility

rheumatoid arthritis to malaria attacks

Variant & Polymorphism SNP	IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect against malaria attacks (

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone   therapeutic potential for bone formation in important bone diseases

ANIMAL & CELL MODELS

mice with expression of IL3 show motor neuron disease with several features of human amyotrophic lateral sclerosis and progressive muscular atrophy.These symptoms are associated with a severe autoimmune reaction against spiral cord motor neurons