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FLASH GENE
Symbol IL27 contributors: mct/ - updated : 21-08-2014
HGNC name interleukin 27
HGNC id 19157
Location 16p11.2      Physical location : 28.510.683 - 28.518.155
Synonym name
  • interleukin 30
  • IL-27 p28 subunit
  • interleukin-27 subunit alpha
    • Synonym symbol(s) IL-27, p28, IL30, IL27p28, IL30, MGC71873, IL-27-A
    DNA
    TYPE functioning gene
    STRUCTURE 7.47 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1044 - 243 - 2002 12121660
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal peptide, several O-glycosylation sites
    • mono polymer heteromer , dimer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • long-chain 4-helix bundle cytokine family
  • IL6 superfamily
  • IL12 family of cytokines
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulation of T cells proliferation, the complex formed with EBI3 drives rapid expansion of naive (but not memory) CD4+ T cells
  • positive regulation of interferon gamma biosynthese through IL12A
  • possesses potent antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities
  • plays a key role in human T cells by promoting IL10-secreting Tr1 cells and inhibiting Th17 cells
  • four-helical cytokine requiring association with the soluble receptor EBI3 to be efficiently secreted and functionally active
  • indirect role for IL27 in shaping the Treg pool
  • inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression
  • has anti-inflammatory properties that regulate T cell polarization and cytokine production
  • cytokine of the IL12 family that plays a key role in the regulation of inflammatory and T cell responses
  • having a pro-inflammatory function in both the adaptive and innate immune responses
  • in contrast to its protective role in limiting CNS autoimmunity and preventing immunopathology, plays a detrimental role in promoting demyelination by delaying viral control in viral infections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric cytokine of the IL-12 family, consists of two subunits, the Epstein-Barr virus-induced gene 3 (EBI3) and p28
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with Epstein-Barr virus gene 3 (EBI3)
  • inhibits IL17A-polarizing cytokines on dendritic cells, which in turn decrease IL17A secretion from T cells
  • IRF1 and IRF9 are sequentially activated and recruited to the IL27 IFN-stimulated regulatory element site
  • interacting with IFNG and SPP1 (important IFNG–dependent self-regulatory process that serves to control immune system homeostasis through an SPP1/IL27 axis in dendritic cells)
  • role of IL27 in regulating complement activation through up-regulation of CFH, suggesting that defects in IL27 signaling or expression may contribute to the reduction of CFH expression in the retina of patients with AMD
  • novel function of IL27 as a direct stimulator of BST2 expression
  • may suppress the production of IL22 by inducing the expression of SOCS1 in human CD4(+) T cells
  • receptor IL17RA with a soluble form that is a natural IL27 antagonist
  • IL27/NFIL3 signalling axis is a key regulator of effector T-cell responses via induction of HAVCR2, IL10 and T-cell dysfunction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    neonatal macrophages express elevated levels of IL27 that oppose immune responses, to contribute to the immunosuppressive environment at the fetal-maternal interface
    constitutional     --low  
    in immune thrombocytopenia (ITP), suggesting that it might be involved in the pathophysiological process of ITP
    Susceptibility
  • to asthma
  • to rheumatoid arthritis (RA)
    • Variant & Polymorphism SNP
  • g.-964A > G polymorphism of IL-27p28 is most likely associated with susceptibility to asthma
  • IL27 -924A/G polymorphism may be involved in susceptibility to RA
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Il27 or Il27 receptor are more susceptible to atherosclerosis compared with wild type due to enhanced accumulation and activation of macrophages in arterial walls