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FLASH GENE

Symbol

IL27

contributors: mct/ - updated : 21-08-2014

HGNC name	interleukin 27
HGNC id	19157

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   neonatal macrophages express elevated levels of IL27 that oppose immune responses, to contribute to the immunosuppressive environment at the fetal-maternal interface constitutional     --low   in immune thrombocytopenia (ITP), suggesting that it might be involved in the pathophysiological process of ITP

Susceptibility

to asthma to rheumatoid arthritis (RA)

Variant & Polymorphism SNP	g.-964A > G polymorphism of IL-27p28 is most likely associated with susceptibility to asthma
	IL27 -924A/G polymorphism may be involved in susceptibility to RA

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking Il27 or Il27 receptor are more susceptible to atherosclerosis compared with wild type due to enhanced accumulation and activation of macrophages in arterial walls