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FLASH GENE

Symbol

IL27

contributors: mct/ - updated : 21-08-2014

HGNC name	interleukin 27
HGNC id	19157

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a N terminal signal peptide, several O-glycosylation sites

mono polymer

heteromer , dimer , complex

HOMOLOGY

Homologene

FAMILY	long-chain 4-helix bundle cytokine family
	IL6 superfamily
	IL12 family of cytokines

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	regulation of T cells proliferation, the complex formed with EBI3 drives rapid expansion of naive (but not memory) CD4+ T cells
	positive regulation of interferon gamma biosynthese through IL12A
	possesses potent antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities
	plays a key role in human T cells by promoting IL10-secreting Tr1 cells and inhibiting Th17 cells
	four-helical cytokine requiring association with the soluble receptor EBI3 to be efficiently secreted and functionally active
	indirect role for IL27 in shaping the Treg pool
	inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression
	has anti-inflammatory properties that regulate T cell polarization and cytokine production
	cytokine of the IL12 family that plays a key role in the regulation of inflammatory and T cell responses
	having a pro-inflammatory function in both the adaptive and innate immune responses
	in contrast to its protective role in limiting CNS autoimmunity and preventing immunopathology, plays a detrimental role in promoting demyelination by delaying viral control in viral infections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

heterodimeric cytokine of the IL-12 family, consists of two subunits, the Epstein-Barr virus-induced gene 3 (EBI3) and p28

INTERACTION

DNA

RNA

small molecule

protein	interacting with Epstein-Barr virus gene 3 (EBI3)
	inhibits IL17A-polarizing cytokines on dendritic cells, which in turn decrease IL17A secretion from T cells
	IRF1 and IRF9 are sequentially activated and recruited to the IL27 IFN-stimulated regulatory element site
	interacting with IFNG and SPP1 (important IFNG–dependent self-regulatory process that serves to control immune system homeostasis through an SPP1/IL27 axis in dendritic cells)
	role of IL27 in regulating complement activation through up-regulation of CFH, suggesting that defects in IL27 signaling or expression may contribute to the reduction of CFH expression in the retina of patients with AMD
	novel function of IL27 as a direct stimulator of BST2 expression
	may suppress the production of IL22 by inducing the expression of SOCS1 in human CD4(+) T cells
	receptor IL17RA with a soluble form that is a natural IL27 antagonist
	IL27/NFIL3 signalling axis is a key regulator of effector T-cell responses via induction of HAVCR2, IL10 and T-cell dysfunction

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   neonatal macrophages express elevated levels of IL27 that oppose immune responses, to contribute to the immunosuppressive environment at the fetal-maternal interface constitutional     --low   in immune thrombocytopenia (ITP), suggesting that it might be involved in the pathophysiological process of ITP

Susceptibility

to asthma to rheumatoid arthritis (RA)

Variant & Polymorphism SNP	g.-964A > G polymorphism of IL-27p28 is most likely associated with susceptibility to asthma
	IL27 -924A/G polymorphism may be involved in susceptibility to RA

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking Il27 or Il27 receptor are more susceptible to atherosclerosis compared with wild type due to enhanced accumulation and activation of macrophages in arterial walls