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FLASH GENE
Symbol IL20 contributors: mct - updated : 02-01-2017
HGNC name interleukin 20
HGNC id 6002
Location 1q32      Physical location : 207.039.153 - 207.042.567
Synonym name four alpha helix cytokine Zcyto10
Synonym symbol(s) IL10D, ZCYTO10, MGC96907, IL-20
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 3.00 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - IL10 - IL19 - IL20 - IL24 - qter
Authors Blumberg (01)
Physical map
LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2 DAF 1q32 decay accelerating factor for complement (CD55, Cromer blood group system) FLJ13310 1q32.1 hypothetical protein FLJ13310 CR2 1q32 complement component (3d/Epstein Barr virus) receptor 2 CR1 1q32 complement component (3b/4b) receptor 1, including Knops blood group system
regionally located tightly linked to IL10, IL19, IL24
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helical cytokine containing six conserved cysteine residues
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Il20
Homologene
FAMILY IL10 family
CATEGORY secretory , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION may be involved in epidermal function and psoriasis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • activating STAT13 in the HaCaT cell lines and stimulatory signal transduction.
  • acting through STAT3
  • important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL20, and other ESR1-responsive genes, in breast cancer cells
  • cell & other
    REGULATION
    induced by enhanced by IL1B,EGF,TNF (TNFA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    inhibition of IL20 and KMT2B may have therapeutic benefits in ESR1-positive breast cancer
    ANIMAL & CELL MODELS
    IL-20 transgenic mice exhibiting aberrant keratin expression in skin