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FLASH GENE
Symbol IL20 contributors: mct - updated : 02-01-2017
HGNC name interleukin 20
HGNC id 6002
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helical cytokine containing six conserved cysteine residues
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Il20
Homologene
FAMILY IL10 family
CATEGORY secretory , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION may be involved in epidermal function and psoriasis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • activating STAT13 in the HaCaT cell lines and stimulatory signal transduction.
  • acting through STAT3
  • important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL20, and other ESR1-responsive genes, in breast cancer cells
  • cell & other
    REGULATION
    induced by enhanced by IL1B,EGF,TNF (TNFA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    inhibition of IL20 and KMT2B may have therapeutic benefits in ESR1-positive breast cancer
    ANIMAL & CELL MODELS
    IL-20 transgenic mice exhibiting aberrant keratin expression in skin