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FLASH GENE
Symbol IL20 contributors: mct - updated : 02-01-2017
HGNC name interleukin 20
HGNC id 6002
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helical cytokine containing six conserved cysteine residues
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Il20
Homologene
FAMILY IL10 family
CATEGORY secretory , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION may be involved in epidermal function and psoriasis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • activating STAT13 in the HaCaT cell lines and stimulatory signal transduction.
  • acting through STAT3
  • important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL20, and other ESR1-responsive genes, in breast cancer cells
    • cell & other
    REGULATION
    induced by enhanced by IL1B,EGF,TNF (TNFA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    inhibition of IL20 and KMT2B may have therapeutic benefits in ESR1-positive breast cancer
    ANIMAL & CELL MODELS
    IL-20 transgenic mice exhibiting aberrant keratin expression in skin