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FLASH GENE
Symbol IL17A contributors: mct/shn - updated : 02-03-2015
HGNC name interleukin 17A
HGNC id 5981
Location 6p12.2      Physical location : 52.051.184 - 52.055.436
Synonym name
  • CTLA-8
  • cytotoxic T-lymphocyte-associated antigen 8
  • cytotoxic T-lymphocyte-associated protein 8
  • cytotoxic T-lymphocyte-associated serine esterase 8
  • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
  • interleukin-17A
  • Synonym symbol(s) CTLA8, IL-17, IL-17A, IL17
    DNA
    TYPE functioning gene
    STRUCTURE 4.25 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D6S1714 - D6S1956 - IL17A - D6S1623 - D6S1960 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1859 - 155 CD4+ T cells - 7499828
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immuneactivated leukocyte Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal hydrophobic signal sequence
  • HOMOLOGY
    interspecies ortholog to il17d, danio rerio
    ortholog to Il17a, Mus musculus
    ortholog to Il17a, Rattus norvegicus
    Homologene
    FAMILY
  • interleukin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • stimulating the production and expression of proinflammatory cytokines IL1B, TNFA by macrophages
  • playing an important role in the initiation and maintenance of the proinflammatory response
  • stimulating the growth of airway epithelial cells through the ERK MAP kinase pathway
  • plays an important role in activating T cells in allergen-specific T cell-mediated immune responses
  • plays a crucial role in the development of collagen-induced arthritis by activating autoantigen-specific cellular and humoral immune responses
  • with IL17RA, activates genes typical of innate immune cytokines, such as TNFalpha and IL-1beta, despite minimal sequence similarity in their respective receptors
  • has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease
  • induced IL-12 production in dendritic cells and mediated Th1 responses
  • involved in chemokine mRNA stabilization in nonmyeloid cells by using a mechanism that is distinct from that operating to control AU-rich mRNA stability in myeloid cells
  • can regulate the expression, proinflammatory properties, and tissue-protective functions of IL22, and indicate that the presence or absence of IL17A governs the proinflammatory versus tissue-protective properties of IL22 in a model of airway damage and inflammation
  • required for optimal host defense against cutaneous candidiasis and may serve as a potential therapy to enhance healing in individuals with chronic cutaneous candidiasi
  • IL17A/IL23A may play a crucial role in autoimmune diseases
  • important mediator in inflammation-associated cancer
  • may promote human tumor angiogenesis, at least in colorectal cancer
  • could stimulate the production of VEGFA in colorectal carcinoma cells, which might be the mechanisms underlying the correlation of IL17A with poor prognosis and angiogenesis
  • essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies
  • IL17A/IL17RA axis increases aortic arch inflammation during atherogenesis through the induction of aortic chemokines, and the acceleration of neutrophil and monocyte recruitment to this site
  • a tight balance between IL2 and the effector cytokine IL17A is essential for immune homeostasis
  • IL23A and IL17A may play an important role in the pathogenesis of primary biliary cirrhosis (PBC) by promoting inflammation
  • IL6 together with IL17A synergistically enhances the expression of survival molecules to hinder critical host defense mechanisms removing virus-infected cells
  • RORC/IL17A axis influences VEGFA production and neovascular retinopathy by mechanisms involving neuroglia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text a proinflammatory cytokine produced by T cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interleukin (IL)-17 receptor
  • IL27 inhibits IL17A-polarizing cytokines on dendritic cells, which in turn decrease IL17A secretion from T cells
  • VEGFA is the most important IL17A-induced angiogenic factor
  • TRAF6 is essential for IL17A/TRAF3IP2-mediated activation of NFKB
  • TRAF6, was critical for IL17A-induced TRAF3IP2 phosphorylation, and for IL17A-induced TBK1 activation, its association with TRAF3IP2, and consequent TRAF3IP2 phosphorylation
  • IL15 has a negative regulatory role in fine-tuning of IL17A production and Th17-mediated inflammation
  • CREM mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease
  • MYD88-dependent IL23R expression contributes to IL17A production
  • IL33, induced by IL17A in epidermal keratinocytes, may be involved in the pathophysiology of inflammatory skin diseases, including psoriasis
  • RORC is a key transcription factor involved in Th17 cell differentiation through direct transcriptional activation of interleukin 17(A) (IL17A)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the invasive group of pituitary adenomas (pMID: 21279695)
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel indicator of prognosis in the patients with colorectal carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    could serve as a novel therapeutic target for colorectal carcinoma
    cancerdigestivecolon
    IL17A and IL17RA are therapeutic targets in colorectal cancer
    ANIMAL & CELL MODELS
  • IL-17-deficient mice display contact, delayed-type, and airway hypersensitivity responses, and reduced T-dependent antibody production
  • IL-17-deficient mice exhibit a markedly suppressed collagen-induced arthritis
  • Mice deficient in IL-17A demonstrated delayed healing and decreased IL-17A production after skin infection with C. albicans