basic FUNCTION
| stimulating the production and expression of proinflammatory cytokines IL1B, TNFA by macrophages |
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playing an important role in the initiation and maintenance of the proinflammatory response |
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stimulating the growth of airway epithelial cells through the ERK MAP kinase pathway |
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plays an important role in activating T cells in allergen-specific T cell-mediated immune responses |
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plays a crucial role in the development of collagen-induced arthritis by activating autoantigen-specific cellular and humoral immune responses |
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with IL17RA, activates genes typical of innate immune cytokines, such as TNFalpha and IL-1beta, despite minimal sequence similarity in their respective receptors |
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has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease |
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induced IL-12 production in dendritic cells and mediated Th1 responses |
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involved in chemokine mRNA stabilization in nonmyeloid cells by using a mechanism that is distinct from that operating to control AU-rich mRNA stability in myeloid cells |
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can regulate the expression, proinflammatory properties, and tissue-protective functions of IL22, and indicate that the presence or absence of IL17A governs the proinflammatory versus tissue-protective properties of IL22 in a model of airway damage and inflammation |
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required for optimal host defense against cutaneous candidiasis and may serve as a potential therapy to enhance healing in individuals with chronic cutaneous candidiasi |
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IL17A/IL23A may play a crucial role in autoimmune diseases |
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important mediator in inflammation-associated cancer |
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may promote human tumor angiogenesis, at least in colorectal cancer |
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could stimulate the production of VEGFA in colorectal carcinoma cells, which might be the mechanisms underlying the correlation of IL17A with poor prognosis and angiogenesis |
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essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies |
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IL17A/IL17RA axis increases aortic arch inflammation during atherogenesis through the induction of aortic chemokines, and the acceleration of neutrophil and monocyte recruitment to this site |
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a tight balance between IL2 and the effector cytokine IL17A is essential for immune homeostasis |
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IL23A and IL17A may play an important role in the pathogenesis of primary biliary cirrhosis (PBC) by promoting inflammation |
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IL6 together with IL17A synergistically enhances the expression of survival molecules to hinder critical host defense mechanisms removing virus-infected cells |
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RORC/IL17A axis influences VEGFA production and neovascular retinopathy by mechanisms involving neuroglia |