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Symbol IGFBP2 contributors: mct - updated : 03-02-2016
HGNC name insulin-like growth factor binding protein 2, 36kDa
HGNC id 5471
Location 2q35      Physical location : 217.498.126 - 217.529.156
Synonym name IGF-binding protein 2
Synonym symbol(s) IBP2, IGBP2, IGF-BP53, BP2
TYPE functioning gene
STRUCTURE 31.03 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ABCA12 2q34 ATP-binding cassette, sub-family A (ABC1), member 12 ATIC 2q35 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase FN1 2q35 fibronectin 1 LOC151575 2q35 similar to MLRQ subunit of the NADH: ubiquinone oxidoreductase complex FLJ10116 2q35 hypothetical protein FLJ10116 PECR 2q35 hypothetical protein FLJ10116 LOC92691 2q35 hypothetical protein BC008604 XRCC5 2q35 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) KIAA1399 2q35 KIAA1399 protein SMARCAL1 2q34-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 RPL37A 2q35 ribosomal protein L37a LOC130700 2q35 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene IGFBP2 2q33-q34 insulin-like growth factor binding protein 2, 36kDa IGFBP5 2q33-q34 insulin-like growth factor binding protein 5 LOC391483 2 similar to ribosomal protein L31 TNP1 2q34-q36 transition protein 1 (during histone to protamine replacement) LOC151363 2q35 hypothetical LOC151363 TNS 2q35-q36 tensin FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1439 - 328 - 2006 17020769
- - 1024 - 181 - 2006 17020769
- - 1343 - 159 - 2006 17020769
- - 1082 - 159 - 2006 17020769
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
 female systemuterus   
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion spinal fluid
physiological period growth/childhood, pregnancy
Text neural tissues, placenta
  • invariant cysteine residues, 12 N terminal, 6 C terminal
  • a N terminal IGFBP motif
  • a central domain lacking cysteine residue, with a RGD motif
  • a thyroglobulin type-I domain
  • two heparin-binding domains (HBDs), contributing differentially to GAG binding in free IGFBP2 and the IGF2/IGFBP2 protein complex
  • C-terminal domains contribute to high-affinity IGF binding, and confer binding specificity and have overlapping but variable interactions with many other molecules, and this C-terminus, but not the RGD domain, of extrinsic IGFBP2 was essential for support of HSC activity
  • secondary structure a thyroglobulin type 1 fold consisting of an alpha-helix, a three-stranded anti-parallel beta-sheet and three flexible loops
    CATEGORY signaling cytokine growth factor
        plasma membrane
    basic FUNCTION
  • having important functions in IGF-I actions in activated microglia/macrophages in the brain
  • major prostatic IGFBP and may be involved in regulating prostate growth
  • oncogenic factor for glioma progression in combination with platelet-derived growth factor-beta (PDGFB)
  • selective malignant factor that may contribute significantly to glioblastoma pathogenesis by enriching for glioma stem cells and mediating their survival
  • as an environmental factor, IGFBP2 supports the survival and cycling of HSCs
  • is an important regulator of osteoclastogenesis and both the heparin- and the IGF-binding domains of IGFBP2 are essential for the formation of fully differentiated and functional osteoclasts
  • NTF3 can synergize with IGFBP2 to promote hematopoietic cell expansion
  • nuclear IGFBP2 is required for the activation of VEGFA expression and consequent angiogenesis
  • is an extrinsic factor that supports the activity of hematopoietic stem cells (HSCs)
  • is a critical cell-autonomous factor that promotes the survival and migration of acute leukemia cells
  • TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, are pro-survival modulators of cell viability in nutrient-deficient microenvironments
  • modulate both IGF and integrin signaling and is a mediator of cell growth, invasion and resistance in other tumor types
  • important novel role of IGFBP2 in regulation of corneal fibroblast differentiation
  • IGF1 and IGFBP2 function coordinately to stimulate AKT1 and osteoblast differentiation
  • CELLULAR PROCESS cell life, proliferation/growth
    text regulation
    a component
  • major IGFBP constituent of the spinal fluid
  • HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development
    small molecule
  • bind insulin-like growth factors I and II (IGF-I/II)
  • IGFBP2 stimulates osteoblast differentiation and this effect is mediated through its heparin-binding domain-1 interacting with PTPRZ1
  • attenuate the biological action of IGF1
  • is the gene most substantially upregulated by TRIB3
  • CD5L binds to IGFBP2, IGFBP3 and IGFBP4, and this interaction may contribute to the mechanism of CD5L-mediated anti-apoptosis function
  • early induction of AMPK in response to IGF1/IGFBP2 followed by suppression is required for osteoblast differentiation
  • IGFBP2/IGF1 stimulated vimentin binding to PTPRZ1 and this was required for PTPRZ1 polymerization
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma multiforme (GBM), and expression is inversely correlated to GBM patient survival
    tumoral     --other  
    deregulated in pancreatic beta cell tumorigenesis
    constitutional     --over  
    increase with age and it is generally assumed that IGFBP2 is a negative predictor of healthy aging
    tumoral     --over  
    in certain human AML and acute lymphoblastic leukemia (ALL) cells
    Susceptibility to breast cancer
    Variant & Polymorphism
    Candidate gene
  • potentialy target for the treatment of prostate cancer
  • IGFBP2 inhibition may be an advantageous clinical approach to ablate the most malignant cancer cells in glioblastoma without off-target effects on normal cells
  • Marker
  • a high circulating level of IGFBP2 is significantly associated with poor survival, suggesting that blood IGFBP2 levels could be a prognostic biomarker for lung cancer
  • may be a useful biomarker integrating the nutritional status, as well as the biological effects of GH, IGF1, and insulin
  • Therapy target
    marker and potential therapeutic target for CDKN2A-deleted gliomas
    neurosensorialvisualanterior chamber
    can be a therapeutic candidate for corneal antifibrotic strategy
  • Igfbp2-null mice have fewer hematopoietic stem cells than wild-type mice