motifs/domains
| invariant cysteine residues, 12 N terminal, 6 C terminal |
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a N terminal IGFBP motif |
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a central domain lacking cysteine residue, with a RGD motif |
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a thyroglobulin type-I domain |
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two heparin-binding domains (HBDs), contributing differentially to GAG binding in free IGFBP2 and the IGF2/IGFBP2 protein complex |
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C-terminal domains contribute to high-affinity IGF binding, and confer binding specificity and have overlapping but variable interactions with many other molecules, and this C-terminus, but not the RGD domain, of extrinsic IGFBP2 was essential for support of HSC activity |
basic FUNCTION
| having important functions in IGF-I actions in activated microglia/macrophages in the brain |
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major prostatic IGFBP and may be involved in regulating prostate growth |
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oncogenic factor for glioma progression in combination with platelet-derived growth factor-beta (PDGFB) |
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selective malignant factor that may contribute significantly to glioblastoma pathogenesis by enriching for glioma stem cells and mediating their survival |
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as an environmental factor, IGFBP2 supports the survival and cycling of HSCs |
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is an important regulator of osteoclastogenesis and both the heparin- and the IGF-binding domains of IGFBP2 are essential for the formation of fully differentiated and functional osteoclasts |
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NTF3 can synergize with IGFBP2 to promote hematopoietic cell expansion |
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nuclear IGFBP2 is required for the activation of VEGFA expression and consequent angiogenesis |
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is an extrinsic factor that supports the activity of hematopoietic stem cells (HSCs) |
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is a critical cell-autonomous factor that promotes the survival and migration of acute leukemia cells |
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TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, are pro-survival modulators of cell viability in nutrient-deficient microenvironments |
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modulate both IGF and integrin signaling and is a mediator of cell growth, invasion and resistance in other tumor types |
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important novel role of IGFBP2 in regulation of corneal fibroblast differentiation |
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IGF1 and IGFBP2 function coordinately to stimulate AKT1 and osteoblast differentiation |