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FLASH GENE
Symbol IGFBP2 contributors: mct - updated : 03-02-2017
HGNC name insulin-like growth factor binding protein 2, 36kDa
HGNC id 5471
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in glioblastoma multiforme (GBM), and expression is inversely correlated to GBM patient survival
tumoral     --other  
deregulated in pancreatic beta cell tumorigenesis
constitutional     --over  
increase with age and it is generally assumed that IGFBP2 is a negative predictor of healthy aging
tumoral     --over  
in certain human AML and acute lymphoblastic leukemia (ALL) cells
tumoral     --over  
in clinical tissues of melanoma compared with the control group, and its expression exhibited a positive association with BSG
Susceptibility to breast cancer
Variant & Polymorphism
Candidate gene
  • potentialy target for the treatment of prostate cancer
  • IGFBP2 inhibition may be an advantageous clinical approach to ablate the most malignant cancer cells in glioblastoma without off-target effects on normal cells
  • Marker
  • a high circulating level of IGFBP2 is significantly associated with poor survival, suggesting that blood IGFBP2 levels could be a prognostic biomarker for lung cancer
  • may be a useful biomarker integrating the nutritional status, as well as the biological effects of GH, IGF1, and insulin
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    marker and potential therapeutic target for CDKN2A-deleted gliomas
    neurosensorialvisualanterior chamber
    can be a therapeutic candidate for corneal antifibrotic strategy
    ANIMAL & CELL MODELS
  • Igfbp2-null mice have fewer hematopoietic stem cells than wild-type mice