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Symbol ID1 contributors: mct/pgu - updated : 08-10-2009
HGNC name inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
HGNC id 5360
Location 20q11.21      Physical location : 30.193.091 - 30.194.313
Synonym name
  • inhibitor of differentiation 1
  • DNA-binding protein inhibitor ID-1
  • helix-loop-helix protein
  • Synonym symbol(s) ID, bHLHb24, ID-1, dJ857M17.1.2
    TYPE functioning gene
    STRUCTURE 1.22 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D20Z1 - ID1 - BCL2L7P1 ,E2F1 - GHRH - qter
    Physical map
    LOC391241 20 similar to Soggy-1 protein precursor (SGY-1) LOC149935 20q11.21 similar to CDK5 regulatory subunit associated protein 3; CDK5 activator-binding protein C53; ischemic heart CDK5 activator-binding protein C53 RPL31P3 20p11-q11 ribosomal protein L31 pseudogene 3 DEFB118 20q11.1-q11.22 defensin, beta 118 DEFB119 20q11.1 defensin, beta 119 DEFB123 20q11.1 defensin, beta 123 REM 20q11.1 RAS (RAD and GEM)-like GTP-binding LOC388794 20 similar to dJ1093G12.6 (A novel protein) HM13 20q11.21 histocompatibility (minor) 13 ID1 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein COX4I2 20q11.21 cytochrome c oxidase subunit IV isoform 2 BCL2L1 20q11.1 BCL2-like 1 TPX2 20q11.2 TPX2, microtubule-associated protein homolog (Xenopus laevis) MYLK2 20q13.31 myosin light chain kinase 2, skeletal muscle FKHL18 20q11.1-q11.2 forkhead-like 18 (Drosophila) DUSP15 20 dual specificity phosphatase-like 15 LOC164395 20q11.21 hypothetical protein LOC164395 C20orf126 20q11.21 chromosome 20 open reading frame 126 LOC343702 20q11.21 similar to dJ310O13.4 (novel protein similar to predicted C. elegans and C. intestinalis proteins) C20orf160 20q11.2 chromosome 20 open reading frame 160 HCK 20q11.21 hemopoietic cell kinase TM9SF4 20q11.21 transmembrane 9 superfamily protein member 4 RPL24P1 20q11 ribosomal protein L24 pseudogene 1 TSPYL3 20q11.1 TSPY-like 3 PLAGL2 20q11.1 pleiomorphic adenoma gene-like 2 POFUT1 20q11 protein O-fucosyltransferase 1 KIF3B 20p11.2-q11.21 kinesin family member 3B ASXL1 20q11 additional sex combs like 1 (Drosophila) DKFZP566G1424 20q11.1-q11.23 hypothetical protein DKFZp566G1424 C20orf112 20q11.1-q11.23 chromosome 20 open reading frame 112
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 993 - 155 - 2001 11278321
  • isoform a
  • 1 splicing 1234 - 149 - 2001 11278321
  • isoform b
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    at STAGE
    physiological period embryo, pregnancy
    cell cycle     cell cycle, interphase, G1
    Text during early development, in progenitor cells, and specifically detected in the epithelial cells of growing ductal structures during early pregnancy
  • basic helix-loop-helix (bHLH) domain
  • conjugated ubiquitinated
    mono polymer heteromer , dimer
    interspecies homolog to murine Id1 (94.6pc)
    homolog to rattus Id1 (92.6pc)
  • helix loop helix family of proteins
  • ID subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • transcriptional repressor of CDKN2A
  • inhibiting transcription factors of the basic helix loop helix family
  • acting as inhibitors of the basic helix-loop-helix (bHLH) transcription factors that control cell differentiation, development and carcinogenesis
  • controlling growth and/or differentiation of several cell types (negatively)
  • potentially required for neurogenesis and angiogenesis (inducing inactivation of p16 (INK4a)/pRB pathway
  • involved in TGF beta 1 signaling pathway in active heterodimers with the b HLH transcription factors through their HLH motifs
  • required for the mobilization of endothelial precursor cells from the bone marrow during pathological tumor angiogenesis, and its expression remains high in tumor neovasculature
  • having tumor-initiating capacity to rare breast cancer cells within the more common types of breast tumors with high lung metastatic potential
  • play an essential role in the regulation of breast epithelial cell differentiation and proliferation
  • attenuates Notch signaling and impairs T-cell commitment by elevating DTX1 expression
  • promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling
  • inhibiting breast cancer cell grotwh through the upregulation of p21 gene expression via the interaction with ERBeta1
  • ID1 and ID3 negatively regulate the transition from lineage-specified hemogenic cells to committed hematopoietic progenitors during hematopoiesis of both embryonic stem cells and induced pluripotent stem cell
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    text B-cell differentiation
    signaling signal transduction
    TGF beta 1 signaling pathway
    a component
    small molecule
  • interacting woth COPS5
  • interacting with ERbeta1
  • ARID3A is a binding partner for ID1 (shares structural similarities with ID1 and recently implicated in TGF-beta1 signaling during embryogenesis
  • NR1D1 could also mediate repression via ID1 binding in the absence of heme
  • regulated BMI1 transcription through MYC binding to its E-box in the promoter
  • link between ID1 and PcG proteins and ID1 may contribute potentially to tumor development through PcG-mediated epigenetic regulation
  • is a novel target of PRKCA signaling (PRKCA signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium)
  • SMURF2 is an E3 ligase that ubiquitinates ID1 and ID3 (SMURF2-mediated ubiquitination and consequent degradation of ID1 or ID3 plays an important role in the regulation of Id expression in senescent cells
  • interaction with LARP6 (LARP6 may be an effective mediator of promoting endothelial proliferation, angiogenesis and wound healing probably by regulating VEGF together with ID1)
  • cell & other
    induced by tumors in enfothelial progenitors cells
    repressed by ZBTB18, repressing ID1, ID2, ID3, ID4 genes during corticogenesis
    Other downregulated as cells differentiate into pre-B and mature B cells
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in prostate cancer tissues
    expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen-receptor
    expression of mRNA in bone marrow and peripheral blood was significantly associated with lymph node metastasis and peritoneal dissemination in gastric carcinoma patients
    Variant & Polymorphism
    Candidate gene
  • plays an important role in polycythemia vera
  • Marker
    Therapy target
  • SystemTypeDisorderPubmed
    upregulation of ID1 in bladder cancer cells lead to increased cell viability in response to epirubicin and downregulation of Id1 increases cellular sensitivity to epirubicin by increased anticancer drug-induced apoptosis
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi